Pharmacokinetics and tissue penetration of vancomycin continuous infusion as prophylaxis for vascular surgery

Christopher J Payne, Alison H Thomson, Adam T Stearns, David G Watson, Tong Zhang, David B Kingsmore, Dominique S Byrne, Alexander S Binning

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13 Citations (Scopus)

Abstract

To determine the tissue penetration of vancomycin into perivascular fat and arterial wall during a continuous infusion of vancomycin, given as prophylaxis for vascular surgery.
Patients undergoing arterial reconstruction requiring antibiotic prophylaxis were included. Patients received a loading infusion of vancomycin the evening prior to surgery followed by a continuous 24 h infusion, calculated according to renal function. Three peri-operative serum samples and intra-operative perivascular fat and arterial wall samples were collected for vancomycin assay.
Twenty-eight patients were included. Three serum samples were obtained from all patients, fat samples were available from 27 (96.4%) patients and vessel wall samples were available from 23 (82.1%) patients. Serum vancomycin concentrations were maintained within a relatively narrow range, while fat and arterial wall concentrations were highly variable.
This study has shown that prophylactic administration of vancomycin with a loading infusion followed by a continuous infusion before and during vascular surgery achieves serum and vascular tissue concentrations that are above the MICs for most common organisms implicated in post-operative graft infection. However, penetration into perivascular fat tissues is poor.
Original languageEnglish
Pages (from-to)2624-2627
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume66
Issue number11
Early online date12 Aug 2011
DOIs
Publication statusPublished - Nov 2011

Keywords

  • glycopeptides
  • surgical prophylaxis
  • tissue distribution

Cite this

Payne, C. J., Thomson, A. H., Stearns, A. T., Watson, D. G., Zhang, T., Kingsmore, D. B., Byrne, D. S., & Binning, A. S. (2011). Pharmacokinetics and tissue penetration of vancomycin continuous infusion as prophylaxis for vascular surgery. Journal of Antimicrobial Chemotherapy , 66(11), 2624-2627. https://doi.org/10.1093/jac/dkr326