Pharmaceutical-grade oral films as substrates for printed medicine

M. Wimmer-Teubenbacher, C. Planchette, H. Pichler, D. Markl, W. K. Hsiao, A. Paudel, S. Stegemann

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In contact-less printing, such as piezo-electric drop on demand printing used in the study, the drop formation process is independent of the substrate. This means that having developed a printable formulation, printed pharmaceutical dosage forms can be obtained on any pharmaceutical grade substrate, such as polymer-based films. In this work we evaluated eight different oral films based on their suitability as printing substrates for sodium picosulfate. The different polymer films were compared regarding printed spot morphology, chemical stability and dissolution profile. The morphology of printed sodium picosulfate was investigated with scanning electron microscopy and optical coherence tomography. The spreading of the deposited drops was found to be governed by the contact angle of the ink with the substrate. The form of the sodium picosulfate drops changed on microcrystalline cellulose films at ambient conditions over 8 weeks and stayed unchanged on other tested substrates. Sodium picosulfate remained amorphous on all substrates according to small and wide angle X-ray scattering, differential scanning calorimetry and polarized light microscopy measurements. The absence of chemical interactions between the drug and substrates, as indicated by infrared spectroscopy, makes all tested substrates suitable for printing sodium picosulfate onto them.

LanguageEnglish
Pages169-180
Number of pages12
JournalInternational Journal of Pharmaceutics
Volume547
Issue number1-2
Early online date18 May 2018
DOIs
Publication statusPublished - 25 Aug 2018

Fingerprint

Printing
Medicine
Pharmaceutical Preparations
Polymers
Polarization Microscopy
Drug Compounding
Ink
Differential Scanning Calorimetry
Dosage Forms
Optical Coherence Tomography
Drug Interactions
Electron Scanning Microscopy
Spectrum Analysis
X-Rays
picosulfate sodium

Keywords

  • dissolution
  • ink jet printing
  • orodispersible film
  • sodium picosulfate

Cite this

Wimmer-Teubenbacher, M., Planchette, C., Pichler, H., Markl, D., Hsiao, W. K., Paudel, A., & Stegemann, S. (2018). Pharmaceutical-grade oral films as substrates for printed medicine. International Journal of Pharmaceutics, 547(1-2), 169-180. https://doi.org/10.1016/j.ijpharm.2018.05.041
Wimmer-Teubenbacher, M. ; Planchette, C. ; Pichler, H. ; Markl, D. ; Hsiao, W. K. ; Paudel, A. ; Stegemann, S. / Pharmaceutical-grade oral films as substrates for printed medicine. In: International Journal of Pharmaceutics. 2018 ; Vol. 547, No. 1-2. pp. 169-180.
@article{044f179963224c969ce89d398d3e1e15,
title = "Pharmaceutical-grade oral films as substrates for printed medicine",
abstract = "In contact-less printing, such as piezo-electric drop on demand printing used in the study, the drop formation process is independent of the substrate. This means that having developed a printable formulation, printed pharmaceutical dosage forms can be obtained on any pharmaceutical grade substrate, such as polymer-based films. In this work we evaluated eight different oral films based on their suitability as printing substrates for sodium picosulfate. The different polymer films were compared regarding printed spot morphology, chemical stability and dissolution profile. The morphology of printed sodium picosulfate was investigated with scanning electron microscopy and optical coherence tomography. The spreading of the deposited drops was found to be governed by the contact angle of the ink with the substrate. The form of the sodium picosulfate drops changed on microcrystalline cellulose films at ambient conditions over 8 weeks and stayed unchanged on other tested substrates. Sodium picosulfate remained amorphous on all substrates according to small and wide angle X-ray scattering, differential scanning calorimetry and polarized light microscopy measurements. The absence of chemical interactions between the drug and substrates, as indicated by infrared spectroscopy, makes all tested substrates suitable for printing sodium picosulfate onto them.",
keywords = "dissolution, ink jet printing, orodispersible film, sodium picosulfate",
author = "M. Wimmer-Teubenbacher and C. Planchette and H. Pichler and D. Markl and Hsiao, {W. K.} and A. Paudel and S. Stegemann",
year = "2018",
month = "8",
day = "25",
doi = "10.1016/j.ijpharm.2018.05.041",
language = "English",
volume = "547",
pages = "169--180",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
number = "1-2",

}

Wimmer-Teubenbacher, M, Planchette, C, Pichler, H, Markl, D, Hsiao, WK, Paudel, A & Stegemann, S 2018, 'Pharmaceutical-grade oral films as substrates for printed medicine' International Journal of Pharmaceutics, vol. 547, no. 1-2, pp. 169-180. https://doi.org/10.1016/j.ijpharm.2018.05.041

Pharmaceutical-grade oral films as substrates for printed medicine. / Wimmer-Teubenbacher, M.; Planchette, C.; Pichler, H.; Markl, D.; Hsiao, W. K.; Paudel, A.; Stegemann, S.

In: International Journal of Pharmaceutics, Vol. 547, No. 1-2, 25.08.2018, p. 169-180.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pharmaceutical-grade oral films as substrates for printed medicine

AU - Wimmer-Teubenbacher, M.

AU - Planchette, C.

AU - Pichler, H.

AU - Markl, D.

AU - Hsiao, W. K.

AU - Paudel, A.

AU - Stegemann, S.

PY - 2018/8/25

Y1 - 2018/8/25

N2 - In contact-less printing, such as piezo-electric drop on demand printing used in the study, the drop formation process is independent of the substrate. This means that having developed a printable formulation, printed pharmaceutical dosage forms can be obtained on any pharmaceutical grade substrate, such as polymer-based films. In this work we evaluated eight different oral films based on their suitability as printing substrates for sodium picosulfate. The different polymer films were compared regarding printed spot morphology, chemical stability and dissolution profile. The morphology of printed sodium picosulfate was investigated with scanning electron microscopy and optical coherence tomography. The spreading of the deposited drops was found to be governed by the contact angle of the ink with the substrate. The form of the sodium picosulfate drops changed on microcrystalline cellulose films at ambient conditions over 8 weeks and stayed unchanged on other tested substrates. Sodium picosulfate remained amorphous on all substrates according to small and wide angle X-ray scattering, differential scanning calorimetry and polarized light microscopy measurements. The absence of chemical interactions between the drug and substrates, as indicated by infrared spectroscopy, makes all tested substrates suitable for printing sodium picosulfate onto them.

AB - In contact-less printing, such as piezo-electric drop on demand printing used in the study, the drop formation process is independent of the substrate. This means that having developed a printable formulation, printed pharmaceutical dosage forms can be obtained on any pharmaceutical grade substrate, such as polymer-based films. In this work we evaluated eight different oral films based on their suitability as printing substrates for sodium picosulfate. The different polymer films were compared regarding printed spot morphology, chemical stability and dissolution profile. The morphology of printed sodium picosulfate was investigated with scanning electron microscopy and optical coherence tomography. The spreading of the deposited drops was found to be governed by the contact angle of the ink with the substrate. The form of the sodium picosulfate drops changed on microcrystalline cellulose films at ambient conditions over 8 weeks and stayed unchanged on other tested substrates. Sodium picosulfate remained amorphous on all substrates according to small and wide angle X-ray scattering, differential scanning calorimetry and polarized light microscopy measurements. The absence of chemical interactions between the drug and substrates, as indicated by infrared spectroscopy, makes all tested substrates suitable for printing sodium picosulfate onto them.

KW - dissolution

KW - ink jet printing

KW - orodispersible film

KW - sodium picosulfate

UR - http://www.scopus.com/inward/record.url?scp=85047815327&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2018.05.041

DO - 10.1016/j.ijpharm.2018.05.041

M3 - Article

VL - 547

SP - 169

EP - 180

JO - International Journal of Pharmaceutics

T2 - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

Wimmer-Teubenbacher M, Planchette C, Pichler H, Markl D, Hsiao WK, Paudel A et al. Pharmaceutical-grade oral films as substrates for printed medicine. International Journal of Pharmaceutics. 2018 Aug 25;547(1-2):169-180. https://doi.org/10.1016/j.ijpharm.2018.05.041