Pharmaceutical film coating catalog for spectral domain optical coherence tomography

Hungyen Lin, Yue Dong, Daniel Markl, Zijian Zhang, Yaochun Shen, J. Axel Zeitler

Research output: Contribution to journalArticle

10 Citations (Scopus)
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Abstract

Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter- and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including OCT are prone to scattering leading to limited penetration, some pharmaceutical coatings may not be measurable altogether. This study presents OCT measurements of 22 different common coatings for the assessment of OCT applicability.

Original languageEnglish
Pages (from-to)3171-3176
Number of pages6
JournalJournal of Pharmaceutical Sciences
Volume106
Issue number10
Early online date15 Jun 2017
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • coating thickness
  • optical coherence tomography
  • pharmaceutical film coating

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