Pharmaceutical film coating catalog for spectral domain optical coherence tomography

Hungyen Lin; Yue Dong; Daniel Markl; Zijian Zhang; Yaochun Shen; J. Axel Zeitler

doi:10.1016/j.xphs.2017.05.032

Pharmaceutical film coating catalog for spectral domain optical coherence tomography

Hungyen Lin^*, Yue Dong, Daniel Markl, Zijian Zhang, Yaochun Shen, J. Axel Zeitler

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

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Abstract

Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter- and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including OCT are prone to scattering leading to limited penetration, some pharmaceutical coatings may not be measurable altogether. This study presents OCT measurements of 22 different common coatings for the assessment of OCT applicability.

Original language	English
Pages (from-to)	3171-3176
Number of pages	6
Journal	Journal of Pharmaceutical Sciences
Volume	106
Issue number	10
Early online date	15 Jun 2017
DOIs	https://doi.org/10.1016/j.xphs.2017.05.032
Publication status	Published - 1 Oct 2017

Keywords

coating thickness
optical coherence tomography
pharmaceutical film coating

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Lin-etal-JPS-2017-Pharmaceutical-film-coating-catalogue-for-spectral-domainFinal published version, 1.2 MBLicence: CC BY 4.0

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abstract = "Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter- and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including OCT are prone to scattering leading to limited penetration, some pharmaceutical coatings may not be measurable altogether. This study presents OCT measurements of 22 different common coatings for the assessment of OCT applicability.",

keywords = "coating thickness, optical coherence tomography, pharmaceutical film coating",

author = "Hungyen Lin and Yue Dong and Daniel Markl and Zijian Zhang and Yaochun Shen and Zeitler, {J. Axel}",

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AU - Lin, Hungyen

AU - Dong, Yue

AU - Markl, Daniel

AU - Zhang, Zijian

AU - Shen, Yaochun

AU - Zeitler, J. Axel

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter- and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including OCT are prone to scattering leading to limited penetration, some pharmaceutical coatings may not be measurable altogether. This study presents OCT measurements of 22 different common coatings for the assessment of OCT applicability.

AB - Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter- and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including OCT are prone to scattering leading to limited penetration, some pharmaceutical coatings may not be measurable altogether. This study presents OCT measurements of 22 different common coatings for the assessment of OCT applicability.

KW - coating thickness

KW - optical coherence tomography

KW - pharmaceutical film coating

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M3 - Article

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JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

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ER -

Pharmaceutical film coating catalog for spectral domain optical coherence tomography

Abstract

Keywords

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