Personalizing health care: feasibility and future implications

Brian Godman, Alexander E Finlayson, Parneet K Cheema, Eva Zebedin-Brandl, Inaki Gutiérrez-Ibarluzea, Jan Jones, Rickard E Malmström, Elina Asola, Christoph Baumgärtel, Marion Bennie, Iain Bishop, Anna Bucsics, Stephen Campbell, Eduardo Diogene, Alessandra Ferrario, Jurij Fürst, Kristina Garuoliene, Miguel Gomes, Katharine Harris, Alan Haycox & 25 others Harald Herholz, Krystyna Hviding, Saira Jan, Marija Kalaba, Christina Kvalheim, Ott Laius, Sven-Ake Lööv, Kamila Malinowska, Andrew Martin, Laura McCullagh, Fredrik Nilsson, Ken Paterson, Ulrich Schwabe, Gisbert Selke, Catherine Sermet, Steven Simoens, Dominik Tomek, Vera Vlahovic-Palcevski, Luka Voncina, Magdalena Wladysiuk, Menno van Woerkom, Durhane Wong-Rieger, Corrine Zara, Raghib Ali, Lars L Gustafsson

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, its promise has not always translated into improvements in patient care due to the complexities involved. There are also concerns that advice for tests has been reversed, current tests can be costly, there is fragmentation of funding of care, and companies may seek high prices for new targeted drugs. There is a need to integrate current knowledge from a payer's perspective to provide future guidance. Multiple findings including general considerations; influence of pharmacogenomics on response and toxicity of drug therapies; value of biomarker tests; limitations and costs of tests; and potentially high acquisition costs of new targeted therapies help to give guidance on potential ways forward for all stakeholder groups. Overall, personalized medicine has the potential to revolutionize care. However, current challenges and concerns need to be addressed to enhance its uptake and funding to benefit patients.

LanguageEnglish
Article number179
Number of pages23
JournalBMC Medicine
Volume11
DOIs
Publication statusPublished - 13 Aug 2013

Fingerprint

Precision Medicine
Delivery of Health Care
Costs and Cost Analysis
Pharmacogenetics
Patient Care
Biomarkers
Phenotype
Drug Therapy
Therapeutics
Pharmaceutical Preparations

Keywords

  • delivery of health care
  • feasibility studies
  • forecasting
  • humans
  • individualized medicine
  • patient care
  • pharmacogenetics
  • reimbursement
  • targeted treatments
  • biomarkers
  • drug development
  • genomics
  • genotyping
  • healthcare policy
  • pharmacogenetics precision medicine
  • personalized medicines
  • health authorities
  • rational use of medicines

Cite this

Godman, B., Finlayson, A. E., Cheema, P. K., Zebedin-Brandl, E., Gutiérrez-Ibarluzea, I., Jones, J., ... Gustafsson, L. L. (2013). Personalizing health care: feasibility and future implications. BMC Medicine, 11, [179]. https://doi.org/10.1186/1741-7015-11-179
Godman, Brian ; Finlayson, Alexander E ; Cheema, Parneet K ; Zebedin-Brandl, Eva ; Gutiérrez-Ibarluzea, Inaki ; Jones, Jan ; Malmström, Rickard E ; Asola, Elina ; Baumgärtel, Christoph ; Bennie, Marion ; Bishop, Iain ; Bucsics, Anna ; Campbell, Stephen ; Diogene, Eduardo ; Ferrario, Alessandra ; Fürst, Jurij ; Garuoliene, Kristina ; Gomes, Miguel ; Harris, Katharine ; Haycox, Alan ; Herholz, Harald ; Hviding, Krystyna ; Jan, Saira ; Kalaba, Marija ; Kvalheim, Christina ; Laius, Ott ; Lööv, Sven-Ake ; Malinowska, Kamila ; Martin, Andrew ; McCullagh, Laura ; Nilsson, Fredrik ; Paterson, Ken ; Schwabe, Ulrich ; Selke, Gisbert ; Sermet, Catherine ; Simoens, Steven ; Tomek, Dominik ; Vlahovic-Palcevski, Vera ; Voncina, Luka ; Wladysiuk, Magdalena ; van Woerkom, Menno ; Wong-Rieger, Durhane ; Zara, Corrine ; Ali, Raghib ; Gustafsson, Lars L. / Personalizing health care : feasibility and future implications. In: BMC Medicine. 2013 ; Vol. 11.
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Godman, B, Finlayson, AE, Cheema, PK, Zebedin-Brandl, E, Gutiérrez-Ibarluzea, I, Jones, J, Malmström, RE, Asola, E, Baumgärtel, C, Bennie, M, Bishop, I, Bucsics, A, Campbell, S, Diogene, E, Ferrario, A, Fürst, J, Garuoliene, K, Gomes, M, Harris, K, Haycox, A, Herholz, H, Hviding, K, Jan, S, Kalaba, M, Kvalheim, C, Laius, O, Lööv, S-A, Malinowska, K, Martin, A, McCullagh, L, Nilsson, F, Paterson, K, Schwabe, U, Selke, G, Sermet, C, Simoens, S, Tomek, D, Vlahovic-Palcevski, V, Voncina, L, Wladysiuk, M, van Woerkom, M, Wong-Rieger, D, Zara, C, Ali, R & Gustafsson, LL 2013, 'Personalizing health care: feasibility and future implications' BMC Medicine, vol. 11, 179. https://doi.org/10.1186/1741-7015-11-179

Personalizing health care : feasibility and future implications. / Godman, Brian; Finlayson, Alexander E; Cheema, Parneet K; Zebedin-Brandl, Eva; Gutiérrez-Ibarluzea, Inaki; Jones, Jan; Malmström, Rickard E; Asola, Elina; Baumgärtel, Christoph; Bennie, Marion; Bishop, Iain; Bucsics, Anna; Campbell, Stephen; Diogene, Eduardo; Ferrario, Alessandra; Fürst, Jurij; Garuoliene, Kristina; Gomes, Miguel; Harris, Katharine; Haycox, Alan; Herholz, Harald; Hviding, Krystyna; Jan, Saira; Kalaba, Marija; Kvalheim, Christina; Laius, Ott; Lööv, Sven-Ake; Malinowska, Kamila; Martin, Andrew; McCullagh, Laura; Nilsson, Fredrik; Paterson, Ken; Schwabe, Ulrich; Selke, Gisbert; Sermet, Catherine; Simoens, Steven; Tomek, Dominik; Vlahovic-Palcevski, Vera; Voncina, Luka; Wladysiuk, Magdalena; van Woerkom, Menno; Wong-Rieger, Durhane; Zara, Corrine; Ali, Raghib; Gustafsson, Lars L.

In: BMC Medicine, Vol. 11, 179, 13.08.2013.

Research output: Contribution to journalArticle

TY - JOUR

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T2 - BMC Medicine

AU - Godman, Brian

AU - Finlayson, Alexander E

AU - Cheema, Parneet K

AU - Zebedin-Brandl, Eva

AU - Gutiérrez-Ibarluzea, Inaki

AU - Jones, Jan

AU - Malmström, Rickard E

AU - Asola, Elina

AU - Baumgärtel, Christoph

AU - Bennie, Marion

AU - Bishop, Iain

AU - Bucsics, Anna

AU - Campbell, Stephen

AU - Diogene, Eduardo

AU - Ferrario, Alessandra

AU - Fürst, Jurij

AU - Garuoliene, Kristina

AU - Gomes, Miguel

AU - Harris, Katharine

AU - Haycox, Alan

AU - Herholz, Harald

AU - Hviding, Krystyna

AU - Jan, Saira

AU - Kalaba, Marija

AU - Kvalheim, Christina

AU - Laius, Ott

AU - Lööv, Sven-Ake

AU - Malinowska, Kamila

AU - Martin, Andrew

AU - McCullagh, Laura

AU - Nilsson, Fredrik

AU - Paterson, Ken

AU - Schwabe, Ulrich

AU - Selke, Gisbert

AU - Sermet, Catherine

AU - Simoens, Steven

AU - Tomek, Dominik

AU - Vlahovic-Palcevski, Vera

AU - Voncina, Luka

AU - Wladysiuk, Magdalena

AU - van Woerkom, Menno

AU - Wong-Rieger, Durhane

AU - Zara, Corrine

AU - Ali, Raghib

AU - Gustafsson, Lars L

PY - 2013/8/13

Y1 - 2013/8/13

N2 - Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, its promise has not always translated into improvements in patient care due to the complexities involved. There are also concerns that advice for tests has been reversed, current tests can be costly, there is fragmentation of funding of care, and companies may seek high prices for new targeted drugs. There is a need to integrate current knowledge from a payer's perspective to provide future guidance. Multiple findings including general considerations; influence of pharmacogenomics on response and toxicity of drug therapies; value of biomarker tests; limitations and costs of tests; and potentially high acquisition costs of new targeted therapies help to give guidance on potential ways forward for all stakeholder groups. Overall, personalized medicine has the potential to revolutionize care. However, current challenges and concerns need to be addressed to enhance its uptake and funding to benefit patients.

AB - Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, its promise has not always translated into improvements in patient care due to the complexities involved. There are also concerns that advice for tests has been reversed, current tests can be costly, there is fragmentation of funding of care, and companies may seek high prices for new targeted drugs. There is a need to integrate current knowledge from a payer's perspective to provide future guidance. Multiple findings including general considerations; influence of pharmacogenomics on response and toxicity of drug therapies; value of biomarker tests; limitations and costs of tests; and potentially high acquisition costs of new targeted therapies help to give guidance on potential ways forward for all stakeholder groups. Overall, personalized medicine has the potential to revolutionize care. However, current challenges and concerns need to be addressed to enhance its uptake and funding to benefit patients.

KW - delivery of health care

KW - feasibility studies

KW - forecasting

KW - humans

KW - individualized medicine

KW - patient care

KW - pharmacogenetics

KW - reimbursement

KW - targeted treatments

KW - biomarkers

KW - drug development

KW - genomics

KW - genotyping

KW - healthcare policy

KW - pharmacogenetics precision medicine

KW - personalized medicines

KW - health authorities

KW - rational use of medicines

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DO - 10.1186/1741-7015-11-179

M3 - Article

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JO - BMC Medicine

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Godman B, Finlayson AE, Cheema PK, Zebedin-Brandl E, Gutiérrez-Ibarluzea I, Jones J et al. Personalizing health care: feasibility and future implications. BMC Medicine. 2013 Aug 13;11. 179. https://doi.org/10.1186/1741-7015-11-179