Perfusion based microfluidic system for pharmacological profiling of neuronal networks

C. MacKerron; G. Robertson; T.J. Bushell; M. Zagnoni

Perfusion based microfluidic system for pharmacological profiling of neuronal networks

C. MacKerron, G. Robertson, T.J. Bushell, M. Zagnoni

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

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Abstract

This work presents the integration of a semi-automated microfluidic platform that utilizes calcium imaging to enable the pharmacological characterization of functionally connected, but environmentally isolated neuronal networks. This approach allows, for the first time, to assess the cause-effect relationship of neuronal communication following drug application, thus allowing the pharmacological characterisation of novel drugs proposed to influence communication between neuronal networks.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Place of Publication	San Diego, CA
Pages	445-446
Number of pages	2
Publication status	Published - 9 Oct 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Convention Center Dublin, Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016 http://www.microtas2016.org/

Conference

Conference	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated title	MicroTas 2016
Country/Territory	Ireland
City	Dublin
Period	9/10/16 → 13/10/16
Internet address	http://www.microtas2016.org/

Keywords

perfusion
microfluidic
neuronal networks
calcium imaging
glutamate
neuronal communication
drug application

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MacKerron-etal-MicroTAS2016-Perfusion-based-microfluidic-system-for-pharmacologicalAccepted author manuscript, 231 KB

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title = "Perfusion based microfluidic system for pharmacological profiling of neuronal networks",

abstract = "This work presents the integration of a semi-automated microfluidic platform that utilizes calcium imaging to enable the pharmacological characterization of functionally connected, but environmentally isolated neuronal networks. This approach allows, for the first time, to assess the cause-effect relationship of neuronal communication following drug application, thus allowing the pharmacological characterisation of novel drugs proposed to influence communication between neuronal networks.",

keywords = "perfusion, microfluidic, neuronal networks, calcium imaging, glutamate, neuronal communication, drug application",

author = "C. MacKerron and G. Robertson and T.J. Bushell and M. Zagnoni",

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MacKerron, C, Robertson, G, Bushell, TJ & Zagnoni, M 2016, Perfusion based microfluidic system for pharmacological profiling of neuronal networks. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, CA, pp. 445-446, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Dublin, Ireland, 9/10/16.

Perfusion based microfluidic system for pharmacological profiling of neuronal networks. / MacKerron, C.; Robertson, G.; Bushell, T.J. et al.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, CA, 2016. p. 445-446.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

TY - GEN

T1 - Perfusion based microfluidic system for pharmacological profiling of neuronal networks

AU - MacKerron, C.

AU - Robertson, G.

AU - Bushell, T.J.

AU - Zagnoni, M.

PY - 2016/10/9

Y1 - 2016/10/9

N2 - This work presents the integration of a semi-automated microfluidic platform that utilizes calcium imaging to enable the pharmacological characterization of functionally connected, but environmentally isolated neuronal networks. This approach allows, for the first time, to assess the cause-effect relationship of neuronal communication following drug application, thus allowing the pharmacological characterisation of novel drugs proposed to influence communication between neuronal networks.

AB - This work presents the integration of a semi-automated microfluidic platform that utilizes calcium imaging to enable the pharmacological characterization of functionally connected, but environmentally isolated neuronal networks. This approach allows, for the first time, to assess the cause-effect relationship of neuronal communication following drug application, thus allowing the pharmacological characterisation of novel drugs proposed to influence communication between neuronal networks.

KW - perfusion

KW - microfluidic

KW - neuronal networks

KW - calcium imaging

KW - glutamate

KW - neuronal communication

KW - drug application

UR - https://cbmsociety.org/conferences/

UR - http://microtas2016.org/

M3 - Conference contribution book

SN - 9781510834163

SP - 445

EP - 446

BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)

CY - San Diego, CA

T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Y2 - 9 October 2016 through 13 October 2016

ER -

Perfusion based microfluidic system for pharmacological profiling of neuronal networks

Abstract

Conference

Keywords

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