Perfusion based microfluidic system for pharmacological profiling of neuronal networks

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Abstract

This work presents the integration of a semi-automated microfluidic platform that utilizes calcium imaging to enable the pharmacological characterization of functionally connected, but environmentally isolated neuronal networks. This approach allows, for the first time, to assess the cause-effect relationship of neuronal communication following drug application, thus allowing the pharmacological characterisation of novel drugs proposed to influence communication between neuronal networks.
Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Place of PublicationSan Diego, CA
Pages445-446
Number of pages2
Publication statusPublished - 9 Oct 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Convention Center Dublin, Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016
http://www.microtas2016.org/

Conference

Conference20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated titleMicroTas 2016
CountryIreland
CityDublin
Period9/10/1613/10/16
Internet address

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Keywords

  • perfusion
  • microfluidic
  • neuronal networks
  • calcium imaging
  • glutamate
  • neuronal communication
  • drug application

Cite this

MacKerron, C., Robertson, G., Bushell, T. J., & Zagnoni, M. (2016). Perfusion based microfluidic system for pharmacological profiling of neuronal networks. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) (pp. 445-446). San Diego, CA.