Performance of ultra-high-density microelectrode arrays

D. E. Gunning, E. J. Chichilnisky, A. M. Litke, V. O'Shea, K. M. Smith, K. Mathieson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Imaging the electrical output activity of biological cells is important to gain an understanding of how cell networks process information. This has implications for the understanding of brain processing, such as that performed by the retina in encoding the visual scene. The performance and electrical quality of a state-of-the-art high-density 519-microelectrode array, that recorded simultaneously
from hundreds of live retinal output cells (ganglion cells) is reported on. The fabrication process for these devices has been optimised and their electrical characteristics examined. The electrode arrays typically exhibit an impedance of 200 kO at 1 kHz and the RMS noise of the whole recording system is 7 mV with a signal to noise ratio of 20:1. With a view to direct stimulation of retinal ganglion cells, a low impedance Z ¼ 300 kO iridium oxide interface capable of delivering large currents Qcap ¼ 4 mC/cm2 to cells was also developed.
LanguageUndefined/Unknown
Pages215-219
Number of pages5
JournalNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume576
Issue number1
DOIs
Publication statusPublished - 11 Jun 2007

Keywords

  • microelectrode arrays
  • optics
  • photonics

Cite this

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title = "Performance of ultra-high-density microelectrode arrays",
abstract = "Imaging the electrical output activity of biological cells is important to gain an understanding of how cell networks process information. This has implications for the understanding of brain processing, such as that performed by the retina in encoding the visual scene. The performance and electrical quality of a state-of-the-art high-density 519-microelectrode array, that recorded simultaneouslyfrom hundreds of live retinal output cells (ganglion cells) is reported on. The fabrication process for these devices has been optimised and their electrical characteristics examined. The electrode arrays typically exhibit an impedance of 200 kO at 1 kHz and the RMS noise of the whole recording system is 7 mV with a signal to noise ratio of 20:1. With a view to direct stimulation of retinal ganglion cells, a low impedance Z ¼ 300 kO iridium oxide interface capable of delivering large currents Qcap ¼ 4 mC/cm2 to cells was also developed.",
keywords = "microelectrode arrays , optics , photonics",
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Performance of ultra-high-density microelectrode arrays. / Gunning, D. E.; Chichilnisky, E. J.; Litke, A. M.; O'Shea, V.; Smith, K. M.; Mathieson, K.

In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 576, No. 1, 11.06.2007, p. 215-219.

Research output: Contribution to journalArticle

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AU - Gunning, D. E.

AU - Chichilnisky, E. J.

AU - Litke, A. M.

AU - O'Shea, V.

AU - Smith, K. M.

AU - Mathieson, K.

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AB - Imaging the electrical output activity of biological cells is important to gain an understanding of how cell networks process information. This has implications for the understanding of brain processing, such as that performed by the retina in encoding the visual scene. The performance and electrical quality of a state-of-the-art high-density 519-microelectrode array, that recorded simultaneouslyfrom hundreds of live retinal output cells (ganglion cells) is reported on. The fabrication process for these devices has been optimised and their electrical characteristics examined. The electrode arrays typically exhibit an impedance of 200 kO at 1 kHz and the RMS noise of the whole recording system is 7 mV with a signal to noise ratio of 20:1. With a view to direct stimulation of retinal ganglion cells, a low impedance Z ¼ 300 kO iridium oxide interface capable of delivering large currents Qcap ¼ 4 mC/cm2 to cells was also developed.

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