Perceptual and acoustic correlates of DBS of subthalamic nucleus versus globus pallidus interna for IPD: a comparative pilot study

K Tjaden, J Greenlee, Fredrik Johannis van Brenk, S Silverman, D Corcos

Research output: Contribution to conferencePoster

Abstract

Purpose: This study compared bilateral deep brain stimulation (DBS) in subthalamic nucleus (STN) versus globus pallidus interna (GPI) on perceived Speech Severity in Parkinson’s disease.
Methods: 12 individuals with STN-DBS and 8 individuals with GPI-DBS were audio-recorded with DBS ON and OFF while reading an excerpt from the Rainbow Passage and producing a conversational monologue. Using a within-speaker, paired comparison paradigm, 10 listeners judged Speech Severity for pairs of stimulation ON-OFF (and OFF-ON) reading passages and monologues masked to stimulation status and speaker group. The proportion of trials for which ON versus OFF stimuli in a given pair was judged to be less severe was calculated.
Results: There was a task effect, with significant results for Rainbow Passage but not conversational monologue. Perceived Speech Severity differed with stimulation status for GPI-DBS but not STN-DBS, with a greater proportion of ON stimulation speech samples judged to be less severe versus OFF samples. At the participant level, response to ON/OFF stimulation was highly variable in STN-DBS group.
Discussion: DBS stimulation differentially impacts perceived speech severity for STN-DBS and GPI-DBS. Results further suggest the perceptual benefit of DBS stimulation may be task specific.
LanguageEnglish
Number of pages1
Publication statusPublished - 24 Feb 2018
Event19th Biennial Conference on Motor Speech - Georgia, United States
Duration: 22 Feb 201825 Feb 2018

Conference

Conference19th Biennial Conference on Motor Speech
CountryUnited States
CityGeorgia
Period22/02/1825/02/18

Fingerprint

Subthalamic Nucleus
Globus Pallidus
Deep Brain Stimulation
Acoustics
Reading
Matched-Pair Analysis
Parkinson Disease

Keywords

  • speech lantuage pathology
  • Parkinson's disease
  • deep brain stimulation

Cite this

Tjaden, K., Greenlee, J., van Brenk, F. J., Silverman, S., & Corcos, D. (2018). Perceptual and acoustic correlates of DBS of subthalamic nucleus versus globus pallidus interna for IPD: a comparative pilot study. Poster session presented at 19th Biennial Conference on Motor Speech, Georgia, United States.
Tjaden, K ; Greenlee, J ; van Brenk, Fredrik Johannis ; Silverman, S ; Corcos, D. / Perceptual and acoustic correlates of DBS of subthalamic nucleus versus globus pallidus interna for IPD : a comparative pilot study. Poster session presented at 19th Biennial Conference on Motor Speech, Georgia, United States.1 p.
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abstract = "Purpose: This study compared bilateral deep brain stimulation (DBS) in subthalamic nucleus (STN) versus globus pallidus interna (GPI) on perceived Speech Severity in Parkinson’s disease. Methods: 12 individuals with STN-DBS and 8 individuals with GPI-DBS were audio-recorded with DBS ON and OFF while reading an excerpt from the Rainbow Passage and producing a conversational monologue. Using a within-speaker, paired comparison paradigm, 10 listeners judged Speech Severity for pairs of stimulation ON-OFF (and OFF-ON) reading passages and monologues masked to stimulation status and speaker group. The proportion of trials for which ON versus OFF stimuli in a given pair was judged to be less severe was calculated. Results: There was a task effect, with significant results for Rainbow Passage but not conversational monologue. Perceived Speech Severity differed with stimulation status for GPI-DBS but not STN-DBS, with a greater proportion of ON stimulation speech samples judged to be less severe versus OFF samples. At the participant level, response to ON/OFF stimulation was highly variable in STN-DBS group. Discussion: DBS stimulation differentially impacts perceived speech severity for STN-DBS and GPI-DBS. Results further suggest the perceptual benefit of DBS stimulation may be task specific.",
keywords = "speech lantuage pathology, Parkinson's disease, deep brain stimulation",
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Tjaden, K, Greenlee, J, van Brenk, FJ, Silverman, S & Corcos, D 2018, 'Perceptual and acoustic correlates of DBS of subthalamic nucleus versus globus pallidus interna for IPD: a comparative pilot study' 19th Biennial Conference on Motor Speech, Georgia, United States, 22/02/18 - 25/02/18, .

Perceptual and acoustic correlates of DBS of subthalamic nucleus versus globus pallidus interna for IPD : a comparative pilot study. / Tjaden, K; Greenlee, J; van Brenk, Fredrik Johannis; Silverman, S; Corcos, D.

2018. Poster session presented at 19th Biennial Conference on Motor Speech, Georgia, United States.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Perceptual and acoustic correlates of DBS of subthalamic nucleus versus globus pallidus interna for IPD

T2 - a comparative pilot study

AU - Tjaden, K

AU - Greenlee, J

AU - van Brenk, Fredrik Johannis

AU - Silverman, S

AU - Corcos, D

PY - 2018/2/24

Y1 - 2018/2/24

N2 - Purpose: This study compared bilateral deep brain stimulation (DBS) in subthalamic nucleus (STN) versus globus pallidus interna (GPI) on perceived Speech Severity in Parkinson’s disease. Methods: 12 individuals with STN-DBS and 8 individuals with GPI-DBS were audio-recorded with DBS ON and OFF while reading an excerpt from the Rainbow Passage and producing a conversational monologue. Using a within-speaker, paired comparison paradigm, 10 listeners judged Speech Severity for pairs of stimulation ON-OFF (and OFF-ON) reading passages and monologues masked to stimulation status and speaker group. The proportion of trials for which ON versus OFF stimuli in a given pair was judged to be less severe was calculated. Results: There was a task effect, with significant results for Rainbow Passage but not conversational monologue. Perceived Speech Severity differed with stimulation status for GPI-DBS but not STN-DBS, with a greater proportion of ON stimulation speech samples judged to be less severe versus OFF samples. At the participant level, response to ON/OFF stimulation was highly variable in STN-DBS group. Discussion: DBS stimulation differentially impacts perceived speech severity for STN-DBS and GPI-DBS. Results further suggest the perceptual benefit of DBS stimulation may be task specific.

AB - Purpose: This study compared bilateral deep brain stimulation (DBS) in subthalamic nucleus (STN) versus globus pallidus interna (GPI) on perceived Speech Severity in Parkinson’s disease. Methods: 12 individuals with STN-DBS and 8 individuals with GPI-DBS were audio-recorded with DBS ON and OFF while reading an excerpt from the Rainbow Passage and producing a conversational monologue. Using a within-speaker, paired comparison paradigm, 10 listeners judged Speech Severity for pairs of stimulation ON-OFF (and OFF-ON) reading passages and monologues masked to stimulation status and speaker group. The proportion of trials for which ON versus OFF stimuli in a given pair was judged to be less severe was calculated. Results: There was a task effect, with significant results for Rainbow Passage but not conversational monologue. Perceived Speech Severity differed with stimulation status for GPI-DBS but not STN-DBS, with a greater proportion of ON stimulation speech samples judged to be less severe versus OFF samples. At the participant level, response to ON/OFF stimulation was highly variable in STN-DBS group. Discussion: DBS stimulation differentially impacts perceived speech severity for STN-DBS and GPI-DBS. Results further suggest the perceptual benefit of DBS stimulation may be task specific.

KW - speech lantuage pathology

KW - Parkinson's disease

KW - deep brain stimulation

UR - https://www.madonna.org/motor-speech-archives

M3 - Poster

ER -

Tjaden K, Greenlee J, van Brenk FJ, Silverman S, Corcos D. Perceptual and acoustic correlates of DBS of subthalamic nucleus versus globus pallidus interna for IPD: a comparative pilot study. 2018. Poster session presented at 19th Biennial Conference on Motor Speech, Georgia, United States.