Peptide-based stimuli-responsive biomaterials

Robert J. Mart, Rachel D. Osborne, Molly M. Stevens, Rein V. Ulijn

Research output: Contribution to journalLiterature reviewpeer-review

454 Citations (Scopus)

Abstract

This article explores recent advances in the design and engineering of materials wholly or principally constructed from peptides. We focus on materials that are able to respond to changes in their environment (pH, ionic strength, temperature, light, oxidation/reduction state, presence of small molecules or the catalytic activity of enzymes) by altering their macromolecular structure. Such peptide-based responsive biomaterials have exciting prospects for a variety of biomedical and bionanotechnology applications in drug delivery, bio-sensing and regenerative medicine.

Original languageEnglish
Pages (from-to)822-835
Number of pages14
JournalSoft Matter
Volume2
Issue number10
Early online date25 Aug 2006
DOIs
Publication statusPublished - 7 Oct 2006

Keywords

  • peptide-based
  • stimuli-responsive biomaterials
  • supramolecular hydrogels
  • elastin-like polypeptide
  • cross-linker
  • nanofibers

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