Patients with Parkinson's disease have a less differentiated muscle activation pattern than healthy controls during manual circle movement

C. M. Toxopeus, B. M. de Jong, G. Valsan, B. A. Conway, J. H. van der Hoeven, K. L. Leenders, N. M. Maurits

    Research output: Contribution to journalConference Contribution

    Abstract

    To investigate changes in modulation of agonist and antagonist activity in patients with Parkinson’s disease (PD) during execution of continuous circle movement. PD patients experience changes in the organization of motor execution inducing problems with initiation and inhibition of movement. This leads to impaired starting and stopping of (purposeful) movement. On the other hand, purposeful movement requires a motor system in which initiation and inhibition of successive movements are adequately organized; the continuous modulation of agonist and antagonist activity. Yet, it is not clear how changes in initiation and inhibition, regarding the agonist-antagonist adjustment, in PD patients cause a decline in the ability to execute purposeful movement. A continuous circle task could provide further insight in specific changes in modulated muscle activity in PD patients. We employed a two-directional, continuous circle task (clockwise and counter clockwise) using a manipulandum with visual feedback. Kinematic and electromyographic (EMG) parameters of 4 lower arm muscles were used to compare (ant)agonist activity between a group of mildly affected PD patients (N515, stage 1-2 Hoehn Yahr) and 2 groups of healthy subjects (elderly, N516 and young subjects, N516). Comparison of kinematic parameters showed that PD patients perform circle movements significantly slower, make more errors and show more variability in task execution compared to both young and elderly subjects. The EMG data showed that PD patients use a less differentiated muscle-activation pattern than young subjects, when executing circle movements. The muscle activation pattern
    of elderly was found to be slightly less differentiated than in young subjects, but still substantially better than in PD patients. We conclude that PD patients, compared to healthy subjects, show changes in kinematics and muscle activation patterns during execution of a continuous circle task. These changes in execution of continuous movement might provide an objective measure of both bradykinesia and rigidity, potentially useful for diagnosis, follow-up of disease progression and further fundamental investigations into these phenomena.
    Original languageEnglish
    Pages (from-to)S346-S346
    Number of pages1
    JournalMovement Disorders
    Volume25
    Issue numberSupplement S2
    DOIs
    Publication statusPublished - May 2010
    EventFourteenth International Congress of Parkinson's Disease and Movement Disorders - Buenos Aires, Argentina
    Duration: 13 Jun 201017 Jun 2010

    Keywords

    • Parkinson’s disease
    • muscle activity

    Cite this

    Toxopeus, C. M., de Jong, B. M., Valsan, G., Conway, B. A., van der Hoeven, J. H., Leenders, K. L., & Maurits, N. M. (2010). Patients with Parkinson's disease have a less differentiated muscle activation pattern than healthy controls during manual circle movement. Movement Disorders, 25(Supplement S2), S346-S346. https://doi.org/10.1002/mds.23162