Patient-reported self-efficacy, anxiety, and health-related quality of life during chemotherapy: results from a longitudinal study

Constantina Papadopoulou, Grigorios Kotronoulas, Annegret Schneider, Morven I. Miller, Jackie McBride, Zoe Polly, Simon Bettles, Alison Whitehouse, Lisa McCann, Nora Kearney, Roma Maguire

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Purpose/Objectives: To explore changes over time in self-efficacy and the predictive ability of changes in state anxiety and health-related quality of life during chemotherapy.
 Design: Secondary analysis of a longitudinal dataset derived from a larger, multicenter study.
 Setting: Outpatient oncology clinics across eight general hospitals in England, Scotland, and Northern Ireland.
 Sample: 137 patients scheduled to receive adjuvant chemotherapy for breast or colorectal cancer.
 Methods: At the beginning of each of six chemotherapy cycles, participants completed the Strategies Used by People to Promote Health questionnaire, the State-Trait Anxiety Inventory, and the Functional Assessment of Cancer Therapy-Breast or -Colorectal questionnaire. Multilevel model analysis was used to analyze longitudinal data, adjusted for demographic and clinical variables.
 Main research variables: Self-efficacy, anxiety, and health-related quality of life.
 Findings: No significant time effects were found for patients' overall perceived self-efficacy or self-efficacy parameters. A trend toward greater self-efficacy was evident as chemotherapy progressed. Self-efficacy was significantly associated with decreased state anxiety throughout chemotherapy. Increases in overall self-efficacy and perceived ability to maintain a positive attitude were significantly associated with over-time increases in physical, emotional, and functional well-being, as well as with fewer cancer-related concerns.
 Conclusions: Findings highlight the importance of clinical assessments throughout treatment that focus on patients' perceived self-efficacy as a positive regulator of mood and well-being. Implications for nursing: The current study suggests self-efficacy enhancement should be a key component of psycho-behavioral programs designed to support patients with cancer throughout chemotherapy.
Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalOncology Nursing Forum
Issue number1
Publication statusPublished - 31 Jan 2017


  • quality of life
  • chemotherapy
  • anxiety
  • self-efficacy


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