Projects per year
Abstract
In this study, the selective crystallization and characterization of the stoichiometric forms of the p-toluenesulfonamide/triphenylphosphine oxide (p-TSA-TPPO) co-crystal system in acetonitrile (MeCN) is demonstrated using batch and semi-batch crystallizers. In the batch study, both 1:1 and 3:2 p-TSA-TPPO were successfully isolated as pure forms. However, process variability was observed in a few experimental runs. To address the batch process variability issue, a control strategy was implemented using temperature cycling, aided by in situ process analytical technologies (PAT) to convert from 3:2 to 1:1 p-TSA-TPPO. In the semi-batch co-crystallization studies, the two molecular co-formers, p-TSA and TPPO, were dissolved in MeCN and pumped separately to the crystallizer. Changing the flow rates of the respective active ingredients allowed control over the co-crystallization outcome, and presents as a promising opportunity for development of a continuous co-crystallization process.
Original language | English |
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Pages (from-to) | 95-108 |
Number of pages | 14 |
Journal | Chemical Engineering Science |
Volume | 152 |
Early online date | 3 Jun 2016 |
DOIs | |
Publication status | Published - 2 Oct 2016 |
Keywords
- co-crystal
- co-crystallization
- process analytical technologies
- stoichiometric
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Dive into the research topics of 'PAT-based design of agrochemical co-crystallization processes: a case-study for the selective crystallization of 1:1 and 3:2 co-crystals of p-toluenesulfonamide/triphenylphosphine oxide'. Together they form a unique fingerprint.Projects
- 1 Finished
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CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation
Florence, A., Bititci, U., Halbert, G., Littlejohn, D. & Sefcik, J.
EPSRC (Engineering and Physical Sciences Research Council)
1/10/11 → 31/12/16
Project: Research