Abstract
Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.
Language | English |
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Number of pages | 27 |
Journal | Chemical Engineering and Technology |
Early online date | 24 Mar 2018 |
DOIs | |
Publication status | E-pub ahead of print - 24 Mar 2018 |
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Keywords
- additives
- amino acids
- chiral separation
- inhibition of crystallization
- preferential crystallization
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Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives. / Kongsamai, Peetikamol; Flood, Chalongsri; ter Horst, Joop H.; Flood, Adrian E.
In: Chemical Engineering and Technology, 24.03.2018.Research output: Contribution to journal › Article
TY - JOUR
T1 - Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives
AU - Kongsamai, Peetikamol
AU - Flood, Chalongsri
AU - ter Horst, Joop H.
AU - Flood, Adrian E.
N1 - This is the pre-peer reviewed version of the following article: Kongsamai, P, Flood, C, ter Horst, JH & Flood, AE 2018, 'Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives' Chemical Engineering and Technology, which has been published in final form at https://doi.org/10.1002/ceat.201700668. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
PY - 2018/3/24
Y1 - 2018/3/24
N2 - Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.
AB - Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.
KW - additives
KW - amino acids
KW - chiral separation
KW - inhibition of crystallization
KW - preferential crystallization
UR - http://www.scopus.com/inward/record.url?scp=85045760625&partnerID=8YFLogxK
UR - https://onlinelibrary.wiley.com/journal/15214125
U2 - 10.1002/ceat.201700668
DO - 10.1002/ceat.201700668
M3 - Article
JO - Chemical Engineering and Technology
T2 - Chemical Engineering and Technology
JF - Chemical Engineering and Technology
SN - 0930-7516
ER -