Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives

Peetikamol Kongsamai, Chalongsri Flood, Joop H. ter Horst, Adrian E. Flood

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2 Citations (Scopus)
23 Downloads (Pure)


Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.

Original languageEnglish
Number of pages27
JournalChemical Engineering and Technology
Early online date24 Mar 2018
Publication statusE-pub ahead of print - 24 Mar 2018


  • additives
  • amino acids
  • chiral separation
  • inhibition of crystallization
  • preferential crystallization

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