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Abstract
Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.
Original language | English |
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Number of pages | 27 |
Journal | Chemical Engineering and Technology |
Early online date | 24 Mar 2018 |
DOIs | |
Publication status | E-pub ahead of print - 24 Mar 2018 |
Keywords
- additives
- amino acids
- chiral separation
- inhibition of crystallization
- preferential crystallization
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Dive into the research topics of 'Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives'. Together they form a unique fingerprint.Projects
- 1 Finished
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CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation
Florence, A., Bititci, U., Halbert, G., Littlejohn, D. & Sefcik, J.
EPSRC (Engineering and Physical Sciences Research Council)
1/10/11 → 31/12/16
Project: Research