Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives

Peetikamol Kongsamai; Chalongsri Flood; Joop H. ter Horst; Adrian E. Flood

doi:10.1002/ceat.201700668

Particle size distributions and performance of preferential crystallization of L-asparagine·H₂O with tailor-made additives

Peetikamol Kongsamai, Chalongsri Flood, Joop H. ter Horst, Adrian E. Flood

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

37 Downloads (Pure)

Abstract

Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H₂O from DL-Asn·H₂O. The amount of pure L-Asn·H₂O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H₂O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H₂O but also the crystal growth of L-Asn·H₂O.

Original language	English
Number of pages	27
Journal	Chemical Engineering and Technology
Early online date	24 Mar 2018
DOIs	https://doi.org/10.1002/ceat.201700668
Publication status	E-pub ahead of print - 24 Mar 2018

Keywords

additives
amino acids
chiral separation
inhibition of crystallization
preferential crystallization

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10.1002/ceat.201700668

Kongsamai-etal-CET2018-Particle-size-distributions-and-performance-of-preferentialAccepted author manuscript, 1.75 MB

Cite this

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title = "Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives",

abstract = "Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.",

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author = "Peetikamol Kongsamai and Chalongsri Flood and {ter Horst}, {Joop H.} and Flood, {Adrian E.}",

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N1 - This is the pre-peer reviewed version of the following article: Kongsamai, P, Flood, C, ter Horst, JH & Flood, AE 2018, 'Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives' Chemical Engineering and Technology, which has been published in final form at https://doi.org/10.1002/ceat.201700668. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

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N2 - Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.

AB - Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.

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Particle size distributions and performance of preferential crystallization of L-asparagine·H₂O with tailor-made additives

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Keywords

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CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation

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Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives

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Particle size distributions and performance of preferential crystallization of L-asparagine·H₂O with tailor-made additives