Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives

Peetikamol Kongsamai, Chalongsri Flood, Joop H. ter Horst, Adrian E. Flood

Research output: Contribution to journal › Article

Abstract

Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.

LanguageEnglish
Number of pages27
JournalChemical Engineering and Technology
Early online date24 Mar 2018
DOIs
StateE-pub ahead of print - 24 Mar 2018

Fingerprint

Asparagine
Crystallization
Particle size analysis
Enantiomers
D-Aspartic Acid
Acids
Crystal growth
Glutamic Acid
Crystals

Keywords

  • additives
  • amino acids
  • chiral separation
  • inhibition of crystallization
  • preferential crystallization

Cite this

Kongsamai, Peetikamol ; Flood, Chalongsri ; ter Horst, Joop H. ; Flood, Adrian E./ Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives. In: Chemical Engineering and Technology. 2018
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abstract = "Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.",
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Kongsamai, P, Flood, C, ter Horst, JH & Flood, AE 2018, 'Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives' Chemical Engineering and Technology. DOI: 10.1002/ceat.201700668

Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives. / Kongsamai, Peetikamol; Flood, Chalongsri; ter Horst, Joop H.; Flood, Adrian E.

In: Chemical Engineering and Technology, 24.03.2018.

Research output: Contribution to journal › Article

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N2 - Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.

AB - Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.

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Kongsamai P, Flood C, ter Horst JH, Flood AE. Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives. Chemical Engineering and Technology. 2018 Mar 24. Available from, DOI: 10.1002/ceat.201700668

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