Parasitic nematode modulation of allergic disease

W. Harnett, M.M. Harnett

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Incidence of allergic diseases such as asthma has increased at an alarming rate in Western countries in the past few decades. However, in parts of the world in which parasitic nematode infections are highly prevalent, allergy remains uncommon. Hence, it has been postulated that nematodes offer humans protection against this type of disease. This article reviews the evidence to support this idea, considering data from human studies and results from investigations into the protective effects of nematodes in animal models of allergic disease. The evidence strongly favors a protective role for nematodes; thus, the search is on to find the molecules involved, with a view toward using them for therapeutic purposes. The article also describes the nature and mode of action of recently characterized nematode-derived molecules with antiallergic properties and highlights their therapeutic efficacy in allergy models.
Original languageEnglish
Pages (from-to)392-397
Number of pages5
JournalCurrent Allergy and Asthma Reports
Volume8
Issue number5
DOIs
Publication statusPublished - Sep 2008

Keywords

  • allergic diseases
  • asthma
  • parasitic nematode modulation

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