Paracetamol habit modification by impurities

Stephanie Urwin; Alan Martin; Joop Ter Horst

Paracetamol habit modification by impurities

Stephanie Urwin, Alan Martin, Joop Ter Horst

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to conference › Poster › peer-review

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Abstract

The presence of impurities during crystallisation can affect final crystal attributes other than chemical purity. For example,metacetamol, a regioisomer of paracetamol, has been reported to modify the morphology of the API, leading to theisolation of columnar crystals in place of crystals with an equant habit. Small scale recrystallisation of pure paracetamolfrom 2-propanol was found here to produce small, relatively equant crystals.

Original language	English
Number of pages	1
Publication status	Published - 9 Jul 2019
Event	50th Annual Conference of the British Association of Crystal Growth - London, United Kingdom Duration: 9 Jul 2019 → 11 Jul 2019

Conference

Conference	50th Annual Conference of the British Association of Crystal Growth
Country/Territory	United Kingdom
City	London
Period	9/07/19 → 11/07/19

Keywords

crystallisation impurities
chemical purity
recrystallisation
paracetomol

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Urwin-etal-BACG50-2019-Paracetamol-habit-modification-byAccepted author manuscript, 253 KB

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title = "Paracetamol habit modification by impurities",

abstract = "The presence of impurities during crystallisation can affect final crystal attributes other than chemical purity. For example,metacetamol, a regioisomer of paracetamol, has been reported to modify the morphology of the API, leading to theisolation of columnar crystals in place of crystals with an equant habit. Small scale recrystallisation of pure paracetamolfrom 2-propanol was found here to produce small, relatively equant crystals.",

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AU - Urwin, Stephanie

AU - Martin, Alan

AU - Ter Horst, Joop

PY - 2019/7/9

Y1 - 2019/7/9

N2 - The presence of impurities during crystallisation can affect final crystal attributes other than chemical purity. For example,metacetamol, a regioisomer of paracetamol, has been reported to modify the morphology of the API, leading to theisolation of columnar crystals in place of crystals with an equant habit. Small scale recrystallisation of pure paracetamolfrom 2-propanol was found here to produce small, relatively equant crystals.

AB - The presence of impurities during crystallisation can affect final crystal attributes other than chemical purity. For example,metacetamol, a regioisomer of paracetamol, has been reported to modify the morphology of the API, leading to theisolation of columnar crystals in place of crystals with an equant habit. Small scale recrystallisation of pure paracetamolfrom 2-propanol was found here to produce small, relatively equant crystals.

KW - crystallisation impurities

KW - chemical purity

KW - recrystallisation

KW - paracetomol

UR - https://www.bacg.co.uk/bacg-50th-annual-conference/

M3 - Poster

T2 - 50th Annual Conference of the British Association of Crystal Growth

Y2 - 9 July 2019 through 11 July 2019

ER -

Paracetamol habit modification by impurities

Abstract

Conference

Keywords

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