Paracetamol habit modification by impurities

Stephanie Urwin, Alan Martin, Joop Ter Horst

Research output: Contribution to conference › Poster

4 Downloads (Pure)

Abstract

The presence of impurities during crystallisation can affect final crystal attributes other than chemical purity. For example,metacetamol, a regioisomer of paracetamol, has been reported to modify the morphology of the API, leading to theisolation of columnar crystals in place of crystals with an equant habit. Small scale recrystallisation of pure paracetamolfrom 2-propanol was found here to produce small, relatively equant crystals.
Original languageEnglish
Number of pages1
Publication statusPublished - 9 Jul 2019
Event50th Annual Conference of the British Association of Crystal Growth - London, United Kingdom
Duration: 9 Jul 2019 → 11 Jul 2019

Conference

Conference50th Annual Conference of the British Association of Crystal Growth
CountryUnited Kingdom
CityLondon
Period9/07/19 → 11/07/19

Fingerprint

2-Propanol
Acetaminophen
Crystallization
Habits

Keywords

  • crystallisation impurities
  • chemical purity
  • recrystallisation
  • paracetomol

Cite this

Urwin, S., Martin, A., & Ter Horst, J. (2019). Paracetamol habit modification by impurities. Poster session presented at 50th Annual Conference of the British Association of Crystal Growth, London, United Kingdom.
Urwin, Stephanie ; Martin, Alan ; Ter Horst, Joop. / Paracetamol habit modification by impurities. Poster session presented at 50th Annual Conference of the British Association of Crystal Growth, London, United Kingdom.1 p.
@conference{bd9d7a01b7ec4565afaeb12b095c3cb6,
title = "Paracetamol habit modification by impurities",
abstract = "The presence of impurities during crystallisation can affect final crystal attributes other than chemical purity. For example,metacetamol, a regioisomer of paracetamol, has been reported to modify the morphology of the API, leading to theisolation of columnar crystals in place of crystals with an equant habit. Small scale recrystallisation of pure paracetamolfrom 2-propanol was found here to produce small, relatively equant crystals.",
keywords = "crystallisation impurities, chemical purity, recrystallisation, paracetomol",
author = "Stephanie Urwin and Alan Martin and {Ter Horst}, Joop",
year = "2019",
month = "7",
day = "9",
language = "English",
note = "50th Annual Conference of the British Association of Crystal Growth ; Conference date: 09-07-2019 Through 11-07-2019",

}

Urwin, S, Martin, A & Ter Horst, J 2019, 'Paracetamol habit modification by impurities', 50th Annual Conference of the British Association of Crystal Growth, London, United Kingdom, 9/07/19 - 11/07/19.

Paracetamol habit modification by impurities. / Urwin, Stephanie; Martin, Alan; Ter Horst, Joop.

2019. Poster session presented at 50th Annual Conference of the British Association of Crystal Growth, London, United Kingdom.

Research output: Contribution to conference › Poster

TY - CONF

T1 - Paracetamol habit modification by impurities

AU - Urwin, Stephanie

AU - Martin, Alan

AU - Ter Horst, Joop

PY - 2019/7/9

Y1 - 2019/7/9

N2 - The presence of impurities during crystallisation can affect final crystal attributes other than chemical purity. For example,metacetamol, a regioisomer of paracetamol, has been reported to modify the morphology of the API, leading to theisolation of columnar crystals in place of crystals with an equant habit. Small scale recrystallisation of pure paracetamolfrom 2-propanol was found here to produce small, relatively equant crystals.

AB - The presence of impurities during crystallisation can affect final crystal attributes other than chemical purity. For example,metacetamol, a regioisomer of paracetamol, has been reported to modify the morphology of the API, leading to theisolation of columnar crystals in place of crystals with an equant habit. Small scale recrystallisation of pure paracetamolfrom 2-propanol was found here to produce small, relatively equant crystals.

KW - crystallisation impurities

KW - chemical purity

KW - recrystallisation

KW - paracetomol

UR - https://www.bacg.co.uk/bacg-50th-annual-conference/

M3 - Poster

ER -

Urwin S, Martin A, Ter Horst J. Paracetamol habit modification by impurities. 2019. Poster session presented at 50th Annual Conference of the British Association of Crystal Growth, London, United Kingdom.

Access to Document