Palladium-catalyzed synthesis of aryl amides through silanoate-mediated hydrolysis of nitriles

Christopher G. McPherson, Keith Livingstone, Craig Jamieson, Iain Simpson

Research output: Contribution to journalArticle

6 Citations (Scopus)
45 Downloads (Pure)

Abstract

A procedure for the formation of aryl amides through the palladium-catalyzed coupling of nitriles and aryl bromides, via the formation of intermediary silanoate derived imidate species is reported. Optimization was undertaken and examples of the process are described that furnish the products in up to 86% isolated yield.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalSynlett
Volume27
Issue number1
Early online date9 Oct 2015
DOIs
Publication statusPublished - 4 Jan 2016

Keywords

  • amidation
  • catalysis
  • hydrolysis
  • nitriles
  • palladium

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