Palladium-catalyzed coupling of hydroxylamines with aryl bromides, chlorides, and iodides

Achim Porzelle, Michael D. Woodrow, Nicholas C. O. Tomkinson

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40 Citations (Scopus)

Abstract

The bis-pyrazole phosphine ligand BippyPhos is effective for the palladium-catalyzed cross-coupling of hydroxylamines with aryl bromides, chlorides, and iodides. Reactions proceed smoothly at 80 °C in toluene in the presence of Cs2CO3 to give synthetically versatile N-arylhydroxylamine products in good to excellent yield.
Original languageUndefined/Unknown
Pages (from-to)233-236
Number of pages4
JournalOrganic Letters
Volume11
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • hydroxylamines
  • aryl bromides
  • palladium-catalyzed coupling
  • chlorides
  • iodides

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