Paediatric Development and Pharmacotherapy

Hannah Batchelor

doi:10.1007/978-3-031-77240-5_2

Paediatric Development and Pharmacotherapy

Hannah Batchelor^*

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Growth and development are major aspects of paediatric populations that are not readily apparent in adults. The process of growth and development encompasses a series of biological processes which greatly influence the pharmacology of medications in children, specifically their pharmacokinetics, which refers to what the body does to a drug, and can be summarised using the acronym ADME: absorption, distribution, metabolism, and elimination. Such influence is linked to alterations in body composition, the maturation of organs and organ systems, and changes in their respective functions, for example, swallowing reflexes, excretion of digestive enzymes, intestinal motility, transit time and intestinal transporters and drug metabolising enzymes. For example, changes in drug efflux transporters result in a decrease or increase in expelling drugs back into the intestinal lumen and thereby in variation in oral bioavailability. Understanding how development can alter drug performance aids in guiding paediatric therapy.

Original language	English
Title of host publication	Pediatric Formulations
Subtitle of host publication	AAPS Advances in the Pharmaceutical Sciences Series
Editors	H. Batchelor, K. Rose
Publisher	Springer
Pages	9-32
Number of pages	24
Volume	58
ISBN (Electronic)	978-3-031-77240-5
ISBN (Print)	978-3-031-77239-9
DOIs	https://doi.org/10.1007/978-3-031-77240-5_2
Publication status	Published - 17 Feb 2026

Publication series

Name	AAPS Advances in the Pharmaceutical Sciences Series
Volume	58
ISSN (Print)	2210-7371
ISSN (Electronic)	2210-738X

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dose selection
Drug elimination
Gastric functionality
Oral absorption
Small intestinal functionality

Access to Document

10.1007/978-3-031-77240-5_2

Cite this

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title = "Paediatric Development and Pharmacotherapy",

abstract = "Growth and development are major aspects of paediatric populations that are not readily apparent in adults. The process of growth and development encompasses a series of biological processes which greatly influence the pharmacology of medications in children, specifically their pharmacokinetics, which refers to what the body does to a drug, and can be summarised using the acronym ADME: absorption, distribution, metabolism, and elimination. Such influence is linked to alterations in body composition, the maturation of organs and organ systems, and changes in their respective functions, for example, swallowing reflexes, excretion of digestive enzymes, intestinal motility, transit time and intestinal transporters and drug metabolising enzymes. For example, changes in drug efflux transporters result in a decrease or increase in expelling drugs back into the intestinal lumen and thereby in variation in oral bioavailability. Understanding how development can alter drug performance aids in guiding paediatric therapy.",

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TY - CHAP

T1 - Paediatric Development and Pharmacotherapy

AU - Batchelor, Hannah

PY - 2026/2/17

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AB - Growth and development are major aspects of paediatric populations that are not readily apparent in adults. The process of growth and development encompasses a series of biological processes which greatly influence the pharmacology of medications in children, specifically their pharmacokinetics, which refers to what the body does to a drug, and can be summarised using the acronym ADME: absorption, distribution, metabolism, and elimination. Such influence is linked to alterations in body composition, the maturation of organs and organ systems, and changes in their respective functions, for example, swallowing reflexes, excretion of digestive enzymes, intestinal motility, transit time and intestinal transporters and drug metabolising enzymes. For example, changes in drug efflux transporters result in a decrease or increase in expelling drugs back into the intestinal lumen and thereby in variation in oral bioavailability. Understanding how development can alter drug performance aids in guiding paediatric therapy.

KW - Dose selection

KW - Drug elimination

KW - Gastric functionality

KW - Oral absorption

KW - Small intestinal functionality

UR - https://www.scopus.com/pages/publications/105030943837

U2 - 10.1007/978-3-031-77240-5_2

DO - 10.1007/978-3-031-77240-5_2

M3 - Chapter

AN - SCOPUS:105030943837

SN - 978-3-031-77239-9

VL - 58

T3 - AAPS Advances in the Pharmaceutical Sciences Series

SP - 9

EP - 32

BT - Pediatric Formulations

A2 - Batchelor, H.

A2 - Rose, K.

PB - Springer

ER -

Paediatric Development and Pharmacotherapy

Abstract

Publication series

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Defining a Paediatric Patient

Global Pediatric Legislation for Pediatric Medicines in LMIC Regions

Modeling and Simulation for Pediatric Formulation Development

Cite this