P72 Characterisation of spinal cord injury induced osteoporosis in a rat model

Elizabeth Tanner; Sylvie Coupaud; Jonathan Williams; James Windmill; John Riddell

doi:10.1002/jbm4.10475

P72 Characterisation of spinal cord injury induced osteoporosis in a rat model

Elizabeth Tanner, Sylvie Coupaud, Jonathan Williams, James Windmill, John Riddell

Research output: Contribution to journal › Conference Contribution › peer-review

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Abstract

Structural,densitometric and mechanical changes that occur in the paralysed limbs of a rat model of complete spinal cord injury (SCI) are described.Providing a uniquely-detailed description of the spatio temporal changes throughout the distal femur (a fracture-prone site in human SCI patients). Male rats (200-250g) were assigned into eight (n=8) experimental groups. Four-groups sustained transection SCI at thoracic level T9 and were sacrificed at 2, 6, 10 and 16-weeks post-surgery. Each SCI group had an age-matched sham-operated control group. Bone quantity and quality were assessed using microCT for global and site-specific analysis of trabecular (epiphyseal and metaphyseal) and cortical bone (metaphyseal and diaphyseal) morphometry and densitometry. Whole-bone and material-level properties were assessed using three-point bending and torsional testing

Original language	English
Article number	e10475
Pages (from-to)	55-56
Number of pages	2
Journal	Journal of Bone and Mineral Research
Volume	5
Issue number	S2
DOIs	https://doi.org/10.1002/jbm4.10475
Publication status	Published - 10 Feb 2021
Event	Bone Research Society Annual Meeting 2019 - Sir Martin Evans Building School of Biosciences, Cardiff University, Cardiff, United Kingdom Duration: 4 Sept 2019 → 6 Sept 2019 https://boneresearchsociety.org/meeting/cardiff2019/

Keywords

spinal cord injury
osteoporosis

Access to Document

10.1002/jbm4.10475

Tanner-etal-JBMR-2021-P72-Characterisation-of-spinal-cord-injury-induced-osteoporosisFinal published version, 159 KBLicence: CC BY 4.0

Medical Devices Doctoral Training Centre Renewal | Williams, Jonathan
Coupaud, S. (Principal Investigator), Windmill, J. (Co-investigator) & Williams, J. (Research Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/14 → 3/05/19
Project: Research Studentship - Internally Allocated

X-ray micro CT Scanner
Windmill, J.
Electronic And Electrical Engineering
Facility/equipment: Equipment

Cite this

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title = "P72 Characterisation of spinal cord injury induced osteoporosis in a rat model",

abstract = "Structural,densitometric and mechanical changes that occur in the paralysed limbs of a rat model of complete spinal cord injury (SCI) are described.Providing a uniquely-detailed description of the spatio temporal changes throughout the distal femur (a fracture-prone site in human SCI patients). Male rats (200-250g) were assigned into eight (n=8) experimental groups. Four-groups sustained transection SCI at thoracic level T9 and were sacrificed at 2, 6, 10 and 16-weeks post-surgery. Each SCI group had an age-matched sham-operated control group. Bone quantity and quality were assessed using microCT for global and site-specific analysis of trabecular (epiphyseal and metaphyseal) and cortical bone (metaphyseal and diaphyseal) morphometry and densitometry. Whole-bone and material-level properties were assessed using three-point bending and torsional testing",

keywords = "spinal cord injury, osteoporosis",

author = "Elizabeth Tanner and Sylvie Coupaud and Jonathan Williams and James Windmill and John Riddell",

year = "2021",

month = feb,

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doi = "10.1002/jbm4.10475",

language = "English",

volume = "5",

pages = "55--56",

journal = "Journal of Bone and Mineral Research",

issn = "0884-0431",

publisher = "Oxford University Press",

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note = "Bone Research Society Annual Meeting 2019, BRS Annual Meeting ; Conference date: 04-09-2019 Through 06-09-2019",

url = "https://boneresearchsociety.org/meeting/cardiff2019/",

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TY - JOUR

T1 - P72 Characterisation of spinal cord injury induced osteoporosis in a rat model

AU - Tanner, Elizabeth

AU - Coupaud, Sylvie

AU - Williams, Jonathan

AU - Windmill, James

AU - Riddell, John

PY - 2021/2/10

Y1 - 2021/2/10

N2 - Structural,densitometric and mechanical changes that occur in the paralysed limbs of a rat model of complete spinal cord injury (SCI) are described.Providing a uniquely-detailed description of the spatio temporal changes throughout the distal femur (a fracture-prone site in human SCI patients). Male rats (200-250g) were assigned into eight (n=8) experimental groups. Four-groups sustained transection SCI at thoracic level T9 and were sacrificed at 2, 6, 10 and 16-weeks post-surgery. Each SCI group had an age-matched sham-operated control group. Bone quantity and quality were assessed using microCT for global and site-specific analysis of trabecular (epiphyseal and metaphyseal) and cortical bone (metaphyseal and diaphyseal) morphometry and densitometry. Whole-bone and material-level properties were assessed using three-point bending and torsional testing

AB - Structural,densitometric and mechanical changes that occur in the paralysed limbs of a rat model of complete spinal cord injury (SCI) are described.Providing a uniquely-detailed description of the spatio temporal changes throughout the distal femur (a fracture-prone site in human SCI patients). Male rats (200-250g) were assigned into eight (n=8) experimental groups. Four-groups sustained transection SCI at thoracic level T9 and were sacrificed at 2, 6, 10 and 16-weeks post-surgery. Each SCI group had an age-matched sham-operated control group. Bone quantity and quality were assessed using microCT for global and site-specific analysis of trabecular (epiphyseal and metaphyseal) and cortical bone (metaphyseal and diaphyseal) morphometry and densitometry. Whole-bone and material-level properties were assessed using three-point bending and torsional testing

KW - spinal cord injury

KW - osteoporosis

U2 - 10.1002/jbm4.10475

DO - 10.1002/jbm4.10475

M3 - Conference Contribution

SN - 0884-0431

VL - 5

SP - 55

EP - 56

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - S2

M1 - e10475

T2 - Bone Research Society Annual Meeting 2019

Y2 - 4 September 2019 through 6 September 2019

ER -

P72 Characterisation of spinal cord injury induced osteoporosis in a rat model

Abstract

Keywords

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Projects

Medical Devices Doctoral Training Centre Renewal | Williams, Jonathan

Equipment

X-ray micro CT Scanner

Cite this