P300 and neuropsychological assessment in mild cognitive impairment and Alzheimer dementia

Mario A. Parra, Lindsay Lorena Ascencio, Hugo Fenando Urquina, Facundo Manes, Agustín M. Ibáñez

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Only a small proportion of individuals with Mild Cognitive Impairment (MCI) will convert to dementia. Methods currently available to identify risk for conversion do not combine enough sensitivity and specificity, which is even more problematic in low-educated populations. Current guidelines suggest the use of combined markers for dementia to enhance the prediction accuracy of assessment methods. The present study adhered to this proposal and investigated the sensitivity and specificity of the electrophysiological component P300 and standard neuropsychological tests to assess patients with Alzheimer's disease (AD) and MCI recruited from a low-income country. The neuropsychological battery comprised tests of memory, attention, language, praxis, and executive functions. The P300 was recorded using a classical visual odd-ball paradigm. Three variables were found to achieve sensitivity and specificity values above 80% (Immediate and Delayed recall of word list - CERAD - and the latency of P300) for both MCI and AD. When they entered the model together (i.e., combined approach) the sensitivity for MCI increased to 96% and the specificity remained high (80%). Our preliminary findings suggest that the combined use of sensitive neuropsychological tasks and the analysis of the P300 may offer a very useful method for the preclinical assessment of AD, particularly in populations with low socioeconomic and educational levels. Our results provide a platform and justification to employ more resources to convert P300 and related parameters into a biological marker for AD.
LanguageEnglish
Article number172
JournalFrontiers in Neurology
Volume3
DOIs
Publication statusPublished - 5 Dec 2012

Fingerprint

Alzheimer Disease
Sensitivity and Specificity
Dementia
P300 Event-Related Potentials
Neuropsychological Tests
Executive Function
Short-Term Memory
Population
Language
Biomarkers
Guidelines
Cognitive Dysfunction

Keywords

  • Alzheimer disease
  • mild cognitive impairment
  • event related potentials
  • P300
  • neuropsychology
  • early detection
  • preclinical markers

Cite this

Parra, Mario A. ; Ascencio, Lindsay Lorena ; Urquina, Hugo Fenando ; Manes, Facundo ; Ibáñez, Agustín M. / P300 and neuropsychological assessment in mild cognitive impairment and Alzheimer dementia. In: Frontiers in Neurology. 2012 ; Vol. 3.
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P300 and neuropsychological assessment in mild cognitive impairment and Alzheimer dementia. / Parra, Mario A.; Ascencio, Lindsay Lorena; Urquina, Hugo Fenando; Manes, Facundo; Ibáñez, Agustín M.

In: Frontiers in Neurology, Vol. 3, 172, 05.12.2012.

Research output: Contribution to journalArticle

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