Abstract
We report here the application of silyl enol ether moieties as efficient alkene coupling partners within cobalt-mediated intramolecular Pauson-Khand reactions. This cyclization strategy delivers synthetically valuable oxygenated cyclopentenone products in yields of ≤93% from both ketone- and aldehyde-derived silyl enol ethers, incorporates both terminal and internal alkyne partners, and delivers a variety of decorated systems, including more complex tricyclic structures. Facile removal of the silyl protecting group reveals oxygenated sites for potential further elaboration.
Original language | English |
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Pages (from-to) | 2750-2755 |
Number of pages | 6 |
Journal | Organic Letters |
Volume | 24 |
Issue number | 14 |
Early online date | 4 Apr 2022 |
DOIs | |
Publication status | Published - 15 Apr 2022 |