Oxygen transfer in a convection-enhanced hollow fiber bioartificial liver

P.D. Hay, A. Veitch, J.D.S. Gaylor

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

A mathematical model was developed to predict oxygen transport in a hollow fiber bioartificial liver device. The model parameters were taken from the HepatAssist 2000 device, a plasma perfused hollow fiber cartridge with primary hepatocytes seeded in the extracapillary space. Cellular oxygen uptake was based on Michaelis-Menten kinetics. Oxygen transport due to the convective flow of plasma into the extracapillary space was considered. The effect of modulating several important parameters was investigated, namely, the Michaelis-Menten constant Vm (the maximum oxygen consumption per unit volume of the cell mass), the oxygen partial pressure, the flow rate of the plasma at device inlet, and the permeability of the cell mass contained in the extracapillary space. A computer implementation of the model was used to assess whether a given number of cells could be maintained within such a device. The results suggest that a substantial proportion of the hepatocytes are exposed to hypoxic conditions under which metabolism may be impaired.
Original languageEnglish
Pages (from-to)119-130
Number of pages11
JournalArtificial Organs
Volume25
Issue number2
DOIs
Publication statusPublished - 20 Dec 2001

Keywords

  • bioartificial liver
  • oxygen transport
  • convection
  • hollow fiber
  • Michaelis-Menten kinetics

Fingerprint Dive into the research topics of 'Oxygen transfer in a convection-enhanced hollow fiber bioartificial liver'. Together they form a unique fingerprint.

  • Cite this