Oxidised phospholipid regulation of toll-like receptor signalling

Clett Erridge, C.M. Spickett

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) serve to initiate inflammatory signalling in response to the detection of conserved microbial molecules or products of host tissue damage. Recent evidence suggests that TLR-signalling plays a considerable role in a number of inflammatory diseases, including atherosclerosis and arthritis. Agents which modulate TLR-signalling are, therefore, receiving interest in terms of their potential to modify inflammatory disease processes. One such family of molecules, the oxidised phospholipids (OxPLs), which are formed as a result of inflammatory events and accumulate at sites of chronic inflammation, have been shown to modulate TLR-signalling in both in vitro and in vivo systems. As the interaction between OxPLs and TLRs may play a significant role in chronic inflammatory disease processes, consideration is given in this review to the potential role of OxPLs in the regulation of TLR-signalling.
LanguageEnglish
Pages76-80
Number of pages4
JournalRedox Report
Volume12
Issue number1-2
DOIs
Publication statusPublished - Feb 2007

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Toll-Like Receptors
Phospholipids
Molecules
Arthritis
Atherosclerosis
Chronic Disease
Tissue
Inflammation

Keywords

  • toll-like receptor
  • signalling
  • oxidised phospholipids
  • atherosclerosis
  • arthritis

Cite this

Erridge, Clett ; Spickett, C.M. / Oxidised phospholipid regulation of toll-like receptor signalling. In: Redox Report. 2007 ; Vol. 12, No. 1-2. pp. 76-80.
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Oxidised phospholipid regulation of toll-like receptor signalling. / Erridge, Clett; Spickett, C.M.

In: Redox Report, Vol. 12, No. 1-2, 02.2007, p. 76-80.

Research output: Contribution to journalArticle

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