Oxidative stress in fungal fermentation processes: the roles of alternative respiration

Q. Li, Z. Bai, A. O'Donnell, L. M. Harvey, P. A. Hoskisson, B. McNeil

Research output: Contribution to journalLiterature review

24 Citations (Scopus)

Abstract

Filamentous fungi are arguably the most industrially important group of microorganisms. Production processes involving these simple eukaryotes are often highly aerobic in nature, which implies these cultures are routinely subject to oxidative stress. Despite this, little is known about how filamentous fungi cope with high levels of oxidative stress as experienced in fermenter systems. More surprisingly, much of our knowledge of oxidative stress responses in fungi comes from environmental or medical studies. Here, the current understanding of oxidative stress effects and cellular responses in filamentous fungi is critically discussed. In particular the role of alternative respiration is evaluated, and the contributions of the alternative oxidase and alternative dehydrogenases in defence against oxidative stress, and their profound influence on fungal metabolism is critically examined. Finally, the importance of further research which would underpin a less empirical approach to optimising fungal strains for the fermenter environment is emphasised.

LanguageEnglish
Pages457-467
Number of pages11
JournalBiotechnology Letters
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 2011

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Oxidative stress
Fermentation
Respiration
Oxidative Stress
Fungi
Fermenters
Eukaryota
Metabolism
Microorganisms
Oxidoreductases
Research

Keywords

  • alternative NADH dehydrogenases
  • alternative oxidase
  • alternative respiratory pathway
  • fungi
  • metabolism
  • oxidative stress
  • aspergillus-niger B1-D
  • neurospora-crassa mitochondria
  • heterologous protein production
  • cyanide-resistant respiration
  • nadh dehydrogenase
  • chemostat cultures
  • ustilago-maydis
  • ubiquinone oxidoreductases
  • saccharomyces-cerevisiae
  • yarrowia-lipolytica

Cite this

Li, Q. ; Bai, Z. ; O'Donnell, A. ; Harvey, L. M. ; Hoskisson, P. A. ; McNeil, B. / Oxidative stress in fungal fermentation processes : the roles of alternative respiration. In: Biotechnology Letters. 2011 ; Vol. 33, No. 3. pp. 457-467.
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Oxidative stress in fungal fermentation processes : the roles of alternative respiration. / Li, Q.; Bai, Z.; O'Donnell, A.; Harvey, L. M.; Hoskisson, P. A.; McNeil, B.

In: Biotechnology Letters, Vol. 33, No. 3, 03.2011, p. 457-467.

Research output: Contribution to journalLiterature review

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