Oxidative stress and the endothelium

Roger M. Wadsworth

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Oxidative stress plays a major role in cardiovascular disease. Despite the widespread acceptance of this view, it remains a challenge to establish the importance of this link in specific disease states because of the numerous pro-oxidant substances and also the many endogenous antioxidant systems that contribute to the imbalance that we term 'oxidative stress'. It seems that the vascular endothelium is particularly sensitive to oxidative stress, and this is one of the mechanisms that results in widespread endothelial dysfunction in most cardiovascular diseases. Moreover, when the endothelium becomes diseased it is itself a source of oxidative stress; however, other components of the vasculature, such as the adventitia, are also important sources of oxidative stress. The symposium Oxidative stress and the endothelium at Life Sciences Meeting, Glasgow, Thursday 12th July 2007 aimed to bring together important new data and concepts that are contributing to the rapid advances in our understanding of this area. Mark Kearney spoke on Insulin resistance and endothelial cell dysfunction, Patrick Pagano spoke on The adventitial fibroblast NAD(P)H oxidase as a paracrine mediator of vascular hypertrophy: signal for vascular disease?, James Lieper spoke on Disruption of methylarginine metabolism impairs vascular homeostasis, and David Newby spoke on Endothelial dysfunction and atherothrombosis.
LanguageEnglish
Pages155-157
Number of pages2
JournalExperimental Physiology
Volume93
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Endothelium
Oxidative Stress
Adventitia
Blood Vessels
Cardiovascular Diseases
Biological Science Disciplines
NADPH Oxidase
Vascular Endothelium
Vascular Diseases
Hypertrophy
Insulin Resistance
Reactive Oxygen Species
Homeostasis
Endothelial Cells
Fibroblasts
Antioxidants

Keywords

  • oxidative stress
  • endothelium
  • pharmacology

Cite this

Wadsworth, Roger M. / Oxidative stress and the endothelium. In: Experimental Physiology. 2008 ; Vol. 93. pp. 155-157.
@article{f6c4efca6f3e4a85812ec6dec8374179,
title = "Oxidative stress and the endothelium",
abstract = "Oxidative stress plays a major role in cardiovascular disease. Despite the widespread acceptance of this view, it remains a challenge to establish the importance of this link in specific disease states because of the numerous pro-oxidant substances and also the many endogenous antioxidant systems that contribute to the imbalance that we term 'oxidative stress'. It seems that the vascular endothelium is particularly sensitive to oxidative stress, and this is one of the mechanisms that results in widespread endothelial dysfunction in most cardiovascular diseases. Moreover, when the endothelium becomes diseased it is itself a source of oxidative stress; however, other components of the vasculature, such as the adventitia, are also important sources of oxidative stress. The symposium Oxidative stress and the endothelium at Life Sciences Meeting, Glasgow, Thursday 12th July 2007 aimed to bring together important new data and concepts that are contributing to the rapid advances in our understanding of this area. Mark Kearney spoke on Insulin resistance and endothelial cell dysfunction, Patrick Pagano spoke on The adventitial fibroblast NAD(P)H oxidase as a paracrine mediator of vascular hypertrophy: signal for vascular disease?, James Lieper spoke on Disruption of methylarginine metabolism impairs vascular homeostasis, and David Newby spoke on Endothelial dysfunction and atherothrombosis.",
keywords = "oxidative stress, endothelium, pharmacology",
author = "Wadsworth, {Roger M.}",
year = "2008",
month = "1",
doi = "10.1113/expphysiol.2007.038687",
language = "English",
volume = "93",
pages = "155--157",
journal = "Experimental Physiology",
issn = "0958-0670",

}

Oxidative stress and the endothelium. / Wadsworth, Roger M.

In: Experimental Physiology, Vol. 93, 01.2008, p. 155-157.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oxidative stress and the endothelium

AU - Wadsworth, Roger M.

PY - 2008/1

Y1 - 2008/1

N2 - Oxidative stress plays a major role in cardiovascular disease. Despite the widespread acceptance of this view, it remains a challenge to establish the importance of this link in specific disease states because of the numerous pro-oxidant substances and also the many endogenous antioxidant systems that contribute to the imbalance that we term 'oxidative stress'. It seems that the vascular endothelium is particularly sensitive to oxidative stress, and this is one of the mechanisms that results in widespread endothelial dysfunction in most cardiovascular diseases. Moreover, when the endothelium becomes diseased it is itself a source of oxidative stress; however, other components of the vasculature, such as the adventitia, are also important sources of oxidative stress. The symposium Oxidative stress and the endothelium at Life Sciences Meeting, Glasgow, Thursday 12th July 2007 aimed to bring together important new data and concepts that are contributing to the rapid advances in our understanding of this area. Mark Kearney spoke on Insulin resistance and endothelial cell dysfunction, Patrick Pagano spoke on The adventitial fibroblast NAD(P)H oxidase as a paracrine mediator of vascular hypertrophy: signal for vascular disease?, James Lieper spoke on Disruption of methylarginine metabolism impairs vascular homeostasis, and David Newby spoke on Endothelial dysfunction and atherothrombosis.

AB - Oxidative stress plays a major role in cardiovascular disease. Despite the widespread acceptance of this view, it remains a challenge to establish the importance of this link in specific disease states because of the numerous pro-oxidant substances and also the many endogenous antioxidant systems that contribute to the imbalance that we term 'oxidative stress'. It seems that the vascular endothelium is particularly sensitive to oxidative stress, and this is one of the mechanisms that results in widespread endothelial dysfunction in most cardiovascular diseases. Moreover, when the endothelium becomes diseased it is itself a source of oxidative stress; however, other components of the vasculature, such as the adventitia, are also important sources of oxidative stress. The symposium Oxidative stress and the endothelium at Life Sciences Meeting, Glasgow, Thursday 12th July 2007 aimed to bring together important new data and concepts that are contributing to the rapid advances in our understanding of this area. Mark Kearney spoke on Insulin resistance and endothelial cell dysfunction, Patrick Pagano spoke on The adventitial fibroblast NAD(P)H oxidase as a paracrine mediator of vascular hypertrophy: signal for vascular disease?, James Lieper spoke on Disruption of methylarginine metabolism impairs vascular homeostasis, and David Newby spoke on Endothelial dysfunction and atherothrombosis.

KW - oxidative stress

KW - endothelium

KW - pharmacology

UR - http://dx.doi.org/10.1113/expphysiol.2007.038687

U2 - 10.1113/expphysiol.2007.038687

DO - 10.1113/expphysiol.2007.038687

M3 - Article

VL - 93

SP - 155

EP - 157

JO - Experimental Physiology

T2 - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

ER -