Oxidation of primary amines to ketones

Deborah A. Knowles; Christopher J. Mathews; Nicholas C. O. Tomkinson

doi:10.1055/s-0028-1083541

Oxidation of primary amines to ketones

Deborah A. Knowles, Christopher J. Mathews, Nicholas C. O. Tomkinson

Pure And Applied Chemistry

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17 Citations (Scopus)

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Abstract

A simple method for the oxidn. of primary amines to the corresponding ketones in the presence of both moisture and air is described. Treatment of an amine with benzoyl peroxide in the presence of Cs2CO3, followed by warming of the hydroxylamine product to 50-70° leads directly to the ketone. The method is shown to be effective for both benzylic and aliph. substrates. [on SciFinder(R)]

Original language	English
Pages (from-to)	2769-2772
Number of pages	4
Journal	Synlett
Issue number	18
DOIs	https://doi.org/10.1055/s-0028-1083541
Publication status	Published - 2008

Keywords

ketones
primary amines

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10.1055/s-0028-1083541

Knowles-Mathews-Tomkinson-Synlett-2008-Oxidation-of-primary-amines-to-ketonesAccepted author manuscript, 248 KB

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title = "Oxidation of primary amines to ketones",

abstract = "A simple method for the oxidn. of primary amines to the corresponding ketones in the presence of both moisture and air is described. Treatment of an amine with benzoyl peroxide in the presence of Cs2CO3, followed by warming of the hydroxylamine product to 50-70° leads directly to the ketone. The method is shown to be effective for both benzylic and aliph. substrates. [on SciFinder(R)]",

keywords = "ketones, primary amines ",

author = "Knowles, \{Deborah A.\} and Mathews, \{Christopher J.\} and Tomkinson, \{Nicholas C. O.\}",

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journal = "Synlett",

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T1 - Oxidation of primary amines to ketones

AU - Knowles, Deborah A.

AU - Mathews, Christopher J.

AU - Tomkinson, Nicholas C. O.

PY - 2008

Y1 - 2008

N2 - A simple method for the oxidn. of primary amines to the corresponding ketones in the presence of both moisture and air is described. Treatment of an amine with benzoyl peroxide in the presence of Cs2CO3, followed by warming of the hydroxylamine product to 50-70° leads directly to the ketone. The method is shown to be effective for both benzylic and aliph. substrates. [on SciFinder(R)]

AB - A simple method for the oxidn. of primary amines to the corresponding ketones in the presence of both moisture and air is described. Treatment of an amine with benzoyl peroxide in the presence of Cs2CO3, followed by warming of the hydroxylamine product to 50-70° leads directly to the ketone. The method is shown to be effective for both benzylic and aliph. substrates. [on SciFinder(R)]

KW - ketones

KW - primary amines

U2 - 10.1055/s-0028-1083541

DO - 10.1055/s-0028-1083541

M3 - Article

SN - 0936-5214

SP - 2769

EP - 2772

JO - Synlett

JF - Synlett

IS - 18

ER -

Oxidation of primary amines to ketones

Abstract

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