Oxidation of primary amines to ketones

Deborah A. Knowles, Christopher J. Mathews, Nicholas C. O. Tomkinson

Research output: Contribution to journalArticle

15 Citations (Scopus)
13 Downloads (Pure)

Abstract

A simple method for the oxidn. of primary amines to the corresponding ketones in the presence of both moisture and air is described. Treatment of an amine with benzoyl peroxide in the presence of Cs2CO3, followed by warming of the hydroxylamine product to 50-70° leads directly to the ketone. The method is shown to be effective for both benzylic and aliph. substrates. [on SciFinder(R)]
Original languageEnglish
Pages (from-to)2769-2772
Number of pages4
JournalSynlett
Issue number18
DOIs
Publication statusPublished - 2008

Keywords

  • ketones
  • primary amines

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