Overcoming drug resistance, the natural way

Matthew I. Hutchings; Katherine R. Duncan

doi:10.1016/j.chom.2022.02.008

Overcoming drug resistance, the natural way

Matthew I. Hutchings, Katherine R. Duncan

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Comment/debate › peer-review

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Abstract

Colistin is an antibiotic of last resort for treating Gram-negative bacterial infections, but resistance is spreading rapidly. In a recent issue of Nature, Wang et al. use genome mining to identify and synthesize a natural variant that bypasses colistin resistance and offers new hope for tackling antimicrobial resistance.

Original language	English
Pages (from-to)	273-274
Number of pages	2
Journal	Cell Host & Microbe
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2022.02.008
Publication status	Published - 9 Mar 2022

Keywords

anti-bacterial agents - pharmacology - therapeutic use
drug resistance
colistin - pharmacology - therapeutic use
humans
gram-negative bacterial Infections - drug therapy

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10.1016/j.chom.2022.02.008

Hutchings-Duncan-CHM-2022-Overcoming-drug-resistance-the-natural-wayAccepted author manuscript, 184 KBLicence: CC BY-NC-ND 4.0

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title = "Overcoming drug resistance, the natural way",

abstract = "Colistin is an antibiotic of last resort for treating Gram-negative bacterial infections, but resistance is spreading rapidly. In a recent issue of Nature, Wang et al. use genome mining to identify and synthesize a natural variant that bypasses colistin resistance and offers new hope for tackling antimicrobial resistance.",

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author = "Hutchings, {Matthew I.} and Duncan, {Katherine R.}",

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AU - Duncan, Katherine R.

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AB - Colistin is an antibiotic of last resort for treating Gram-negative bacterial infections, but resistance is spreading rapidly. In a recent issue of Nature, Wang et al. use genome mining to identify and synthesize a natural variant that bypasses colistin resistance and offers new hope for tackling antimicrobial resistance.

KW - anti-bacterial agents - pharmacology - therapeutic use

KW - drug resistance

KW - colistin - pharmacology - therapeutic use

KW - humans

KW - gram-negative bacterial Infections - drug therapy

U2 - 10.1016/j.chom.2022.02.008

DO - 10.1016/j.chom.2022.02.008

M3 - Comment/debate

C2 - 35271795

VL - 30

SP - 273

EP - 274

IS - 3

ER -

Overcoming drug resistance, the natural way

Abstract

Keywords

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