Outcomes of tocilizumab therapy in severe or critical COVID-19 patients: a retrospective cohort, single-centre study

Hassan Abdelnaby, Wael Aboelhassan, Mohammed Al-Jarallah, Rajesh Rajan, Raja Dashti, Ahmad R. Al Saber, Ahmed Abd el-Saleem, Islam Ashri, Mohammed Abdullah, Ahmed Mahmud Fouad

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To assess the effectiveness and safety of tocilizumab, a humanised anti-interleukin-6 receptor antibody, in the treatment of critical or severe coronavirus disease 2019 (COVID-19) patients. Methods: This was a retrospective cohort study of severe or critical COVID-19 patients (≥18 years) admitted to one hospital in Kuwait. Fifty-one patients received intravenous tocilizumab, while 78 patients received the standard of care at the same hospital. Both groups were compared for clinical improvement and in-hospital mortality. Results: The tocilizumab (TCZ) group had a significantly lower 28-day in-hospital mortality rate than the standard-of care-group (21.6% vs. 42.3% respectively; p = 0.015). Fifty-five per cent of patients in the TCZ group clinically improved vs. 11.5% in the standard-of-care group (p < 0.001). Using Cox-proportional regression analysis, TCZ treatment was associated with a reduced risk of mortality (adjusted hazard ratio 0.25; 95% CI: 0.11–0.61) and increased likelihood of clinical improvement (adjusted hazard ratio 4.94; 95% CI: 2.03–12.0), compared to the standard of care. The median C-reactive protein, D-dimer, procalcitonin, lactate dehydrogenase and ferritin levels in the tocilizumab group decreased significantly over the 14 days of follow-up. Secondary infections occurred in 19.6% of the TCZ group, and in 20.5% of the standard-of-care group, with no statistical significance (p = 0.900). Conclusion: Tocilizumab was significantly associated with better survival and greater clinical improvement in severe or critical COVID-19 patients.

Original languageEnglish
JournalTropical Medicine and International Health
Early online date3 Oct 2021
DOIs
Publication statusE-pub ahead of print - 3 Oct 2021

Keywords

  • Covid-19
  • tocilizumab
  • mortality
  • survival
  • Kuwait

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