Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization

Thomas McGlone, Naomi E. B. Briggs, Catriona A. Clark, Cameron J. Brown, Jan Sefcik, Alastair J. Florence

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Continuous crystallization is an attractive approach for the delivery of consistent particles with specified critical quality attributes (CQAs), which are attracting increased interest for the manufacture of high value materials, including fine chemicals and pharmaceuticals. Oscillatory flow reactors (OFRs) offer a suitable platform to deliver consistent operating conditions under plug-flow operation while maintaining a controlled steady state. This review provides a brief overview of OFR technology before outlining the operating principles and summarizing applications, emphasizing the use for controlled continuous crystallization. While significant progress has been made to date, areas for further development are highlighted that will enhance the range of applications and ease of implementation of OFR technology. These depend on specific applications but include scale down, materials of construction suitable for chemical compatibility, encrustation mitigation, the enhancement of robust operation via automation, process analytical technology (PAT), and real-time feedback control.
LanguageEnglish
Pages1186–1202
Number of pages17
JournalOrganic Process Research and Development
Volume19
Issue number9
Early online date6 Aug 2015
DOIs
Publication statusPublished - 18 Sep 2015

Fingerprint

Crystallization
manufacturing
reactor technology
reactors
crystallization
Real time control
chemical compatibility
Feedback control
Automation
plugs
automation
feedback control
delivery
platforms
Pharmaceutical Preparations
augmentation

Keywords

  • continuous crystallization
  • critical quality attributes
  • oscillatory flow reactors
  • process analytical technology

Cite this

@article{cf8a1678818d42a8b2283292a4a3d4ff,
title = "Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization",
abstract = "Continuous crystallization is an attractive approach for the delivery of consistent particles with specified critical quality attributes (CQAs), which are attracting increased interest for the manufacture of high value materials, including fine chemicals and pharmaceuticals. Oscillatory flow reactors (OFRs) offer a suitable platform to deliver consistent operating conditions under plug-flow operation while maintaining a controlled steady state. This review provides a brief overview of OFR technology before outlining the operating principles and summarizing applications, emphasizing the use for controlled continuous crystallization. While significant progress has been made to date, areas for further development are highlighted that will enhance the range of applications and ease of implementation of OFR technology. These depend on specific applications but include scale down, materials of construction suitable for chemical compatibility, encrustation mitigation, the enhancement of robust operation via automation, process analytical technology (PAT), and real-time feedback control.",
keywords = "continuous crystallization, critical quality attributes, oscillatory flow reactors, process analytical technology",
author = "Thomas McGlone and Briggs, {Naomi E. B.} and Clark, {Catriona A.} and Brown, {Cameron J.} and Jan Sefcik and Florence, {Alastair J.}",
year = "2015",
month = "9",
day = "18",
doi = "10.1021/acs.oprd.5b00225",
language = "English",
volume = "19",
pages = "1186–1202",
journal = "Organic Process Research and Development",
issn = "1083-6160",
publisher = "American Chemical Society",
number = "9",

}

Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization. / McGlone, Thomas; Briggs, Naomi E. B.; Clark, Catriona A.; Brown, Cameron J.; Sefcik, Jan; Florence, Alastair J.

In: Organic Process Research and Development, Vol. 19, No. 9, 18.09.2015, p. 1186–1202.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization

AU - McGlone, Thomas

AU - Briggs, Naomi E. B.

AU - Clark, Catriona A.

AU - Brown, Cameron J.

AU - Sefcik, Jan

AU - Florence, Alastair J.

PY - 2015/9/18

Y1 - 2015/9/18

N2 - Continuous crystallization is an attractive approach for the delivery of consistent particles with specified critical quality attributes (CQAs), which are attracting increased interest for the manufacture of high value materials, including fine chemicals and pharmaceuticals. Oscillatory flow reactors (OFRs) offer a suitable platform to deliver consistent operating conditions under plug-flow operation while maintaining a controlled steady state. This review provides a brief overview of OFR technology before outlining the operating principles and summarizing applications, emphasizing the use for controlled continuous crystallization. While significant progress has been made to date, areas for further development are highlighted that will enhance the range of applications and ease of implementation of OFR technology. These depend on specific applications but include scale down, materials of construction suitable for chemical compatibility, encrustation mitigation, the enhancement of robust operation via automation, process analytical technology (PAT), and real-time feedback control.

AB - Continuous crystallization is an attractive approach for the delivery of consistent particles with specified critical quality attributes (CQAs), which are attracting increased interest for the manufacture of high value materials, including fine chemicals and pharmaceuticals. Oscillatory flow reactors (OFRs) offer a suitable platform to deliver consistent operating conditions under plug-flow operation while maintaining a controlled steady state. This review provides a brief overview of OFR technology before outlining the operating principles and summarizing applications, emphasizing the use for controlled continuous crystallization. While significant progress has been made to date, areas for further development are highlighted that will enhance the range of applications and ease of implementation of OFR technology. These depend on specific applications but include scale down, materials of construction suitable for chemical compatibility, encrustation mitigation, the enhancement of robust operation via automation, process analytical technology (PAT), and real-time feedback control.

KW - continuous crystallization

KW - critical quality attributes

KW - oscillatory flow reactors

KW - process analytical technology

UR - http://pubs.acs.org/journal/oprdfk

U2 - 10.1021/acs.oprd.5b00225

DO - 10.1021/acs.oprd.5b00225

M3 - Article

VL - 19

SP - 1186

EP - 1202

JO - Organic Process Research and Development

T2 - Organic Process Research and Development

JF - Organic Process Research and Development

SN - 1083-6160

IS - 9

ER -