Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization

Thomas McGlone, Naomi E. B. Briggs, Catriona A. Clark, Cameron J. Brown, Jan Sefcik, Alastair J. Florence

Research output: Contribution to journalArticle

91 Citations (Scopus)
168 Downloads (Pure)

Abstract

Continuous crystallization is an attractive approach for the delivery of consistent particles with specified critical quality attributes (CQAs), which are attracting increased interest for the manufacture of high value materials, including fine chemicals and pharmaceuticals. Oscillatory flow reactors (OFRs) offer a suitable platform to deliver consistent operating conditions under plug-flow operation while maintaining a controlled steady state. This review provides a brief overview of OFR technology before outlining the operating principles and summarizing applications, emphasizing the use for controlled continuous crystallization. While significant progress has been made to date, areas for further development are highlighted that will enhance the range of applications and ease of implementation of OFR technology. These depend on specific applications but include scale down, materials of construction suitable for chemical compatibility, encrustation mitigation, the enhancement of robust operation via automation, process analytical technology (PAT), and real-time feedback control.
Original languageEnglish
Pages (from-to)1186–1202
Number of pages17
JournalOrganic Process Research and Development
Volume19
Issue number9
Early online date6 Aug 2015
DOIs
Publication statusPublished - 18 Sep 2015

Keywords

  • continuous crystallization
  • critical quality attributes
  • oscillatory flow reactors
  • process analytical technology

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