Tetrahydrothiophene is an efficient organocatalyst for the synthesis of highly substituted furfuryl products from readily accessible electron-poor enynes under neutral reaction conditions. This process is applicable to a wide range of nucleophiles and enynes and can be used in a domino organocatalysis sequence.
- domino reacitons
Clark, S., Boyer, A., Aimon, A., Garcia, P. E., Lindsay, D. M., Symington, A. D. F., & Danoy, Y. (2012). Organocatalytic synthesis of highly substituted furfuryl alcohols and amines. Angewandte Chemie International Edition , 51(48), 12128-12131. https://doi.org/10.1002/anie.201207300