Organobase-catalyzed amidation of esters with amino alcohols

Nicola Caldwell, Craig Jamieson, Iain Simpson, Tell Tuttle

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

Original languageEnglish
Pages (from-to)2506-2509
Number of pages4
JournalOrganic Letters
Volume15
Issue number10
Early online date2 May 2013
DOIs
Publication statusPublished - 17 May 2013

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Amino Alcohols
esters
Esters
alcohols
optimization
products

Keywords

  • reagents
  • convenient
  • catalytic process
  • unactivated esters
  • efficient
  • carboxylic acids

Cite this

Caldwell, Nicola ; Jamieson, Craig ; Simpson, Iain ; Tuttle, Tell. / Organobase-catalyzed amidation of esters with amino alcohols. In: Organic Letters. 2013 ; Vol. 15, No. 10. pp. 2506-2509.
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Organobase-catalyzed amidation of esters with amino alcohols. / Caldwell, Nicola; Jamieson, Craig; Simpson, Iain; Tuttle, Tell.

In: Organic Letters, Vol. 15, No. 10, 17.05.2013, p. 2506-2509.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Organobase-catalyzed amidation of esters with amino alcohols

AU - Caldwell, Nicola

AU - Jamieson, Craig

AU - Simpson, Iain

AU - Tuttle, Tell

PY - 2013/5/17

Y1 - 2013/5/17

N2 - A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

AB - A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

KW - reagents

KW - convenient

KW - catalytic process

KW - unactivated esters

KW - efficient

KW - carboxylic acids

UR - http://pubs.acs.org/journal/orlef7

U2 - 10.1021/ol400987p

DO - 10.1021/ol400987p

M3 - Article

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