Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs

Laura Mooney; Louise Marks; Karen L Philp; Matthew Skinner; Susan J Coker; Susan Currie

doi:10.1016/j.vascn.2012.05.008

Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs

Laura Mooney
, Louise Marks
, Karen L Philp
, Matthew Skinner
, Susan J Coker
, Susan Currie

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Detecting adverse effects of drugs on cardiac contractility is becoming a priority in pre-clinical safety pharmacology. The aim of this work was to optimise conditions and explore the potential of using the anaesthetized guinea pig as an in vivo model.

Original language	English
Pages (from-to)	43-51
Number of pages	9
Journal	Journal of Pharmacological and Toxicological Methods
Volume	66
Issue number	1
DOIs	https://doi.org/10.1016/j.vascn.2012.05.008
Publication status	Published - Jul 2012

Keywords

anaesthesia
cardiac contractility
guinea pig
inotropes
isoprenaline
verapamil

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10.1016/j.vascn.2012.05.008

Cite this

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title = "Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs",

abstract = "Detecting adverse effects of drugs on cardiac contractility is becoming a priority in pre-clinical safety pharmacology. The aim of this work was to optimise conditions and explore the potential of using the anaesthetized guinea pig as an in vivo model.",

keywords = "anaesthesia, cardiac contractility, guinea pig, inotropes, isoprenaline, verapamil",

author = "Laura Mooney and Louise Marks and Philp, \{Karen L\} and Matthew Skinner and Coker, \{Susan J\} and Susan Currie",

year = "2012",

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AU - Mooney, Laura

AU - Marks, Louise

AU - Philp, Karen L

AU - Skinner, Matthew

AU - Coker, Susan J

AU - Currie, Susan

PY - 2012/7

Y1 - 2012/7

N2 - Detecting adverse effects of drugs on cardiac contractility is becoming a priority in pre-clinical safety pharmacology. The aim of this work was to optimise conditions and explore the potential of using the anaesthetized guinea pig as an in vivo model.

AB - Detecting adverse effects of drugs on cardiac contractility is becoming a priority in pre-clinical safety pharmacology. The aim of this work was to optimise conditions and explore the potential of using the anaesthetized guinea pig as an in vivo model.

KW - anaesthesia

KW - cardiac contractility

KW - guinea pig

KW - inotropes

KW - isoprenaline

KW - verapamil

UR - https://www.scopus.com/pages/publications/84864080579

U2 - 10.1016/j.vascn.2012.05.008

DO - 10.1016/j.vascn.2012.05.008

M3 - Article

C2 - 22659057

VL - 66

SP - 43

EP - 51

JO - Journal of Pharmacological and Toxicological Methods

JF - Journal of Pharmacological and Toxicological Methods

IS - 1

ER -

Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs

Abstract

Keywords

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