Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs

Laura Mooney, Louise Marks, Karen L Philp, Matthew Skinner, Susan J Coker, Susan Currie

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Detecting adverse effects of drugs on cardiac contractility is becoming a priority in pre-clinical safety pharmacology. The aim of this work was to optimise conditions and explore the potential of using the anaesthetized guinea pig as an in vivo model.
Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalJournal of Pharmacological and Toxicological Methods
Volume66
Issue number1
DOIs
Publication statusPublished - Jul 2012

Keywords

  • anaesthesia
  • cardiac contractility
  • guinea pig
  • inotropes
  • isoprenaline
  • verapamil

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