Detecting adverse effects of drugs on cardiac contractility is becoming a priority in pre-clinical safety pharmacology. The aim of this work was to optimise conditions and explore the potential of using the anaesthetized guinea pig as an in vivo model.
|Number of pages||9|
|Journal||Journal of Pharmacological and Toxicological Methods|
|Publication status||Published - Jul 2012|
- cardiac contractility
- guinea pig
Mooney, L., Marks, L., Philp, K. L., Skinner, M., Coker, S. J., & Currie, S. (2012). Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs. Journal of Pharmacological and Toxicological Methods , 66(1), 43-51. https://doi.org/10.1016/j.vascn.2012.05.008