Optimisation of the enantioselective synthesis of cyanohydrin esters

L. Veum, L.T. Kanerva, P.J. Halling, T. Maschmeyer, U. Hanefeld

Research output: Contribution to journal › Article

63 Citations (Scopus)

Abstract

The base- and lipase-catalysed enantioselective synthesis of cyanohydrin esters was investigated, and the problem of previously reported low yields due to residual water in the reaction mixture was addressed. When the lipase was immobilised on Celite R-633 as a carrier, both the enantioselectivity and the reaction times for this dynamic kinetic resolution were improved, thus enabling a highly enantioselective synthesis of aromatic and heteroaromatic cyanohydrin acetates.
LanguageEnglish
Pages1015-1021
Number of pages6
JournalAdvanced Synthesis and Catalysis
Volume347
Issue number7-8
DOIs
Publication statusPublished - 2005

Fingerprint

Lipases
Lipase
Esters
Diatomaceous Earth
Enantioselectivity
Acetates
Kinetics
Water
cyanohydrin

Keywords

  • asymmetric synthesis
  • Celite
  • dynamic kinetic resolution
  • enzyme catalysis
  • lipase B from Candida antarctica

Cite this

Veum, L. ; Kanerva, L.T. ; Halling, P.J. ; Maschmeyer, T. ; Hanefeld, U. / Optimisation of the enantioselective synthesis of cyanohydrin esters. In: Advanced Synthesis and Catalysis. 2005 ; Vol. 347, No. 7-8. pp. 1015-1021.
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Veum, L, Kanerva, LT, Halling, PJ, Maschmeyer, T & Hanefeld, U 2005, 'Optimisation of the enantioselective synthesis of cyanohydrin esters' Advanced Synthesis and Catalysis, vol. 347, no. 7-8, pp. 1015-1021. https://doi.org/10.1002/adsc.200505031

Optimisation of the enantioselective synthesis of cyanohydrin esters. / Veum, L.; Kanerva, L.T.; Halling, P.J.; Maschmeyer, T.; Hanefeld, U.

In: Advanced Synthesis and Catalysis, Vol. 347, No. 7-8, 2005, p. 1015-1021.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Optimisation of the enantioselective synthesis of cyanohydrin esters

AU - Veum, L.

AU - Kanerva, L.T.

AU - Halling, P.J.

AU - Maschmeyer, T.

AU - Hanefeld, U.

PY - 2005

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KW - asymmetric synthesis

KW - Celite

KW - dynamic kinetic resolution

KW - enzyme catalysis

KW - lipase B from Candida antarctica

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Veum L, Kanerva LT, Halling PJ, Maschmeyer T, Hanefeld U. Optimisation of the enantioselective synthesis of cyanohydrin esters. Advanced Synthesis and Catalysis. 2005;347(7-8):1015-1021. https://doi.org/10.1002/adsc.200505031

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