Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus

H. B. Liu, R. Edrada-Ebel, R. Ebel, Y. Wang, B. Schulz, S. Draeger, W. E. G. Muller, V. Wray, W. H. Lin, P. Proksch

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Abstract

Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1–5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.
Original languageEnglish
Pages (from-to)623-631
Number of pages9
JournalHelvetica Chimica Acta
Volume94
Issue number4
Early online date11 Apr 2011
DOIs
Publication statusPublished - Apr 2011

Keywords

  • metabolites
  • aspergillus ustus
  • suberites domuncula
  • fungi
  • sesterterpenoids
  • pyrrolidine alkaloids
  • cytotoxic activity
  • alkaloids

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    Liu, H. B., Edrada-Ebel, R., Ebel, R., Wang, Y., Schulz, B., Draeger, S., Muller, W. E. G., Wray, V., Lin, W. H., & Proksch, P. (2011). Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus. Helvetica Chimica Acta, 94(4), 623-631. https://doi.org/10.1002/hlca.201000283