Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus

H. B. Liu; R. Edrada-Ebel; R. Ebel; Y. Wang; B. Schulz; S. Draeger; W. E. G. Muller; V. Wray; W. H. Lin; P. Proksch

doi:10.1002/hlca.201000283

Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus

H. B. Liu, R. Edrada-Ebel, R. Ebel, Y. Wang, B. Schulz, S. Draeger, W. E. G. Muller, V. Wray, W. H. Lin, P. Proksch

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1–5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.

Original language	English
Pages (from-to)	623-631
Number of pages	9
Journal	Helvetica Chimica Acta
Volume	94
Issue number	4
Early online date	11 Apr 2011
DOIs	https://doi.org/10.1002/hlca.201000283
Publication status	Published - Apr 2011

Keywords

metabolites
aspergillus ustus
suberites domuncula
fungi
sesterterpenoids
pyrrolidine alkaloids
cytotoxic activity
alkaloids

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10.1002/hlca.201000283

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abstract = "Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1–5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.",

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AU - Liu, H. B.

AU - Edrada-Ebel, R.

AU - Ebel, R.

AU - Wang, Y.

AU - Schulz, B.

AU - Draeger, S.

AU - Muller, W. E. G.

AU - Wray, V.

AU - Lin, W. H.

AU - Proksch, P.

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AB - Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1–5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.

KW - metabolites

KW - aspergillus ustus

KW - suberites domuncula

KW - fungi

KW - sesterterpenoids

KW - pyrrolidine alkaloids

KW - cytotoxic activity

KW - alkaloids

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DO - 10.1002/hlca.201000283

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JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 4

ER -

Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus

Abstract

Keywords

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