Projects per year
Abstract
We report a method for observing and quantifying antisolvent crystallization (acetone/water system) of paracetamol in an oscillatory baffled crystallizer (OBC). With the help of optical means, paracetamol crystals passing the light sheet are recorded by a CCD camera. This allows the mass of crystals to be tracked with time and in turn the instantaneous and overall averaged crystal mass growth rates to be evaluated. By the standard sampling method, the overall averaged crystal growth rate and the percentage recovery of crystals were also determined. This work shows that there is a high correlation in data between the optical and the sampling techniques, validating the accuracy and reliability of the system. Our data are also consistent with previous work in this field.
Original language | English |
---|---|
Pages (from-to) | 719-725 |
Number of pages | 7 |
Journal | Crystal Growth and Design |
Volume | 11 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2 Mar 2011 |
Keywords
- oscillatory baffled crystallizer
- paracetamol crystals
- crystal mass growth
Fingerprint
Dive into the research topics of 'Online evaluation of paracetamol antisolvent crystallization growth rate with video imaging in an oscillatory baffled crystallizer'. Together they form a unique fingerprint.Projects
- 1 Finished
-
CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation
Florence, A., Bititci, U., Halbert, G., Littlejohn, D. & Sefcik, J.
EPSRC (Engineering and Physical Sciences Research Council)
1/10/11 → 31/12/16
Project: Research