@article{c2588b7a81dd4203b3f178bbc6c3a112,
title = "One-pot synthesis, crystallization and deracemization of isoindolinones from achiral reactants",
abstract = "The synthesis, crystallization, and complete solid-state deracemization of isoindolinones was realized in one pot simply by grinding achiral reaction components in a suitable solvent with an achiral catalyst. Previously, this concept was applied to a reversible reaction, but herein we showed that it could also be used in combination with reactions in which product formation is irreversible. A controlled final configuration of the product was obtained by using small amounts of chiral additives or seed crystals of the product.",
keywords = "chiral resolution, chirality, heterocycles, multicomponent reactions, synthesis design",
author = "Steendam, {Ren{\'e} R E} and Kulka, {Micha{\"e}l W.} and Hugo Meekes and {Van Enckevort}, {Willem J P} and Jan Raap and Elias Vlieg and Rutjes, {Floris P J T}",
note = "This is the peer reviewed version of the following article: Steendam, R. R. E., Kulka, M. W., Meekes, H., Van Enckevort, W. J. P., Raap, J., Vlieg, E., & Rutjes, F. P. J. T. (2015). One-pot synthesis, crystallization and deracemization of isoindolinones from achiral reactants. European Journal of Organic Chemistry, 2015(33), 7249-7252., which has been published in final form at http://dx.doi.org/10.1002/ejoc.201501191. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.",
year = "2015",
month = nov,
day = "1",
doi = "10.1002/ejoc.201501191",
language = "English",
volume = "2015",
pages = "7249--7252",
journal = "European Journal of Organic Chemistry",
issn = "1434-193X",
publisher = "Wiley-VCH Verlag",
number = "33",
}