One-pot four-component reaction for the generation of pyrazoles and pyrimidines

Jeffrey Stonehouse; Dmitriy Chekmarev; Natalya Ivanova; Stuart Lang; Garry Pairaudeau; Neal Smith; Michael Stocks; Sergey Sviridov; Lyubov Utkina

doi:10.1055/s-2007-1000839

One-pot four-component reaction for the generation of pyrazoles and pyrimidines

Jeffrey Stonehouse, Dmitriy Chekmarev, Natalya Ivanova, Stuart Lang, Garry Pairaudeau, Neal Smith, Michael Stocks, Sergey Sviridov, Lyubov Utkina

Pure And Applied Chemistry

Research output: Contribution to journal › Letter

44 Citations (Scopus)

Abstract

The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process

Original language	English
Pages (from-to)	100-104
Number of pages	5
Journal	Synlett
Issue number	1
Early online date	11 Dec 2007
DOIs	https://doi.org/10.1055/s-2007-1000839
Publication status	Published - 2008

Keywords

carbonylations
combinatorial chemistry
heterocycles
multicomponent reactions
palladium

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10.1055/s-2007-1000839

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title = "One-pot four-component reaction for the generation of pyrazoles and pyrimidines",

abstract = "The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process",

keywords = "carbonylations, combinatorial chemistry, heterocycles, multicomponent reactions, palladium",

author = "Jeffrey Stonehouse and Dmitriy Chekmarev and Natalya Ivanova and Stuart Lang and Garry Pairaudeau and Neal Smith and Michael Stocks and Sergey Sviridov and Lyubov Utkina",

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T1 - One-pot four-component reaction for the generation of pyrazoles and pyrimidines

AU - Stonehouse, Jeffrey

AU - Chekmarev, Dmitriy

AU - Ivanova, Natalya

AU - Lang, Stuart

AU - Pairaudeau, Garry

AU - Smith, Neal

AU - Stocks, Michael

AU - Sviridov, Sergey

AU - Utkina, Lyubov

PY - 2008

Y1 - 2008

N2 - The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process

AB - The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process

KW - carbonylations

KW - combinatorial chemistry

KW - heterocycles

KW - multicomponent reactions

KW - palladium

U2 - 10.1055/s-2007-1000839

DO - 10.1055/s-2007-1000839

M3 - Letter

SP - 100

EP - 104

JO - Synlett

JF - Synlett

SN - 0936-5214

IS - 1

ER -