One-pot four-component reaction for the generation of pyrazoles and pyrimidines

Jeffrey Stonehouse, Dmitriy Chekmarev, Natalya Ivanova, Stuart Lang, Garry Pairaudeau, Neal Smith, Michael Stocks, Sergey Sviridov, Lyubov Utkina

Research output: Contribution to journalLetterpeer-review

50 Citations (Scopus)


The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process
Original languageEnglish
Pages (from-to)100-104
Number of pages5
Issue number1
Early online date11 Dec 2007
Publication statusPublished - 2008


  • carbonylations
  • combinatorial chemistry
  • heterocycles
  • multicomponent reactions
  • palladium


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