One-pot four-component reaction for the generation of pyrazoles and pyrimidines

Jeffrey Stonehouse, Dmitriy Chekmarev, Natalya Ivanova, Stuart Lang, Garry Pairaudeau, Neal Smith, Michael Stocks, Sergey Sviridov, Lyubov Utkina

Research output: Contribution to journalLetter

39 Citations (Scopus)

Abstract

The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process
LanguageEnglish
Pages100-104
Number of pages5
JournalSynlett
Issue number1
Early online date11 Dec 2007
DOIs
Publication statusPublished - 2008

Fingerprint

hydrazine
Pyrazoles
Amidines
Pyrimidines
Alkynes
Palladium
hexacarbonylmolybdenum

Keywords

  • carbonylations
  • combinatorial chemistry
  • heterocycles
  • multicomponent reactions
  • palladium

Cite this

Stonehouse, J., Chekmarev, D., Ivanova, N., Lang, S., Pairaudeau, G., Smith, N., ... Utkina, L. (2008). One-pot four-component reaction for the generation of pyrazoles and pyrimidines. Synlett, (1), 100-104. https://doi.org/10.1055/s-2007-1000839
Stonehouse, Jeffrey ; Chekmarev, Dmitriy ; Ivanova, Natalya ; Lang, Stuart ; Pairaudeau, Garry ; Smith, Neal ; Stocks, Michael ; Sviridov, Sergey ; Utkina, Lyubov. / One-pot four-component reaction for the generation of pyrazoles and pyrimidines. In: Synlett. 2008 ; No. 1. pp. 100-104.
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Stonehouse, J, Chekmarev, D, Ivanova, N, Lang, S, Pairaudeau, G, Smith, N, Stocks, M, Sviridov, S & Utkina, L 2008, 'One-pot four-component reaction for the generation of pyrazoles and pyrimidines' Synlett, no. 1, pp. 100-104. https://doi.org/10.1055/s-2007-1000839

One-pot four-component reaction for the generation of pyrazoles and pyrimidines. / Stonehouse, Jeffrey; Chekmarev, Dmitriy; Ivanova, Natalya; Lang, Stuart; Pairaudeau, Garry; Smith, Neal; Stocks, Michael; Sviridov, Sergey; Utkina, Lyubov.

In: Synlett, No. 1, 2008, p. 100-104.

Research output: Contribution to journalLetter

TY - JOUR

T1 - One-pot four-component reaction for the generation of pyrazoles and pyrimidines

AU - Stonehouse, Jeffrey

AU - Chekmarev, Dmitriy

AU - Ivanova, Natalya

AU - Lang, Stuart

AU - Pairaudeau, Garry

AU - Smith, Neal

AU - Stocks, Michael

AU - Sviridov, Sergey

AU - Utkina, Lyubov

PY - 2008

Y1 - 2008

N2 - The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process

AB - The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process

KW - carbonylations

KW - combinatorial chemistry

KW - heterocycles

KW - multicomponent reactions

KW - palladium

U2 - 10.1055/s-2007-1000839

DO - 10.1055/s-2007-1000839

M3 - Letter

SP - 100

EP - 104

JO - Synlett

T2 - Synlett

JF - Synlett

SN - 0936-5214

IS - 1

ER -

Stonehouse J, Chekmarev D, Ivanova N, Lang S, Pairaudeau G, Smith N et al. One-pot four-component reaction for the generation of pyrazoles and pyrimidines. Synlett. 2008;(1):100-104. https://doi.org/10.1055/s-2007-1000839