One-pot four-component reaction for the generation of pyrazoles and pyrimidines

Jeffrey Stonehouse; Dmitriy Chekmarev; Natalya Ivanova; Stuart Lang; Garry Pairaudeau; Neal Smith; Michael Stocks; Sergey Sviridov; Lyubov Utkina

doi:10.1055/s-2007-1000839

One-pot four-component reaction for the generation of pyrazoles and pyrimidines

Jeffrey Stonehouse, Dmitriy Chekmarev, Natalya Ivanova, Stuart Lang, Garry Pairaudeau, Neal Smith, Michael Stocks, Sergey Sviridov, Lyubov Utkina

Pure And Applied Chemistry

Research output: Contribution to journal › Letter

41 Citations (Scopus)

Abstract

The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process

Original language	English
Pages (from-to)	100-104
Number of pages	5
Journal	Synlett
Issue number	1
Early online date	11 Dec 2007
DOIs	https://doi.org/10.1055/s-2007-1000839
Publication status	Published - 2008

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Keywords

carbonylations
combinatorial chemistry
heterocycles
multicomponent reactions
palladium

Cite this

Stonehouse, J., Chekmarev, D., Ivanova, N., Lang, S., Pairaudeau, G., Smith, N., ... Utkina, L. (2008). One-pot four-component reaction for the generation of pyrazoles and pyrimidines. Synlett, (1), 100-104. https://doi.org/10.1055/s-2007-1000839

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AU - Pairaudeau, Garry

AU - Smith, Neal

AU - Stocks, Michael

AU - Sviridov, Sergey

AU - Utkina, Lyubov

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AB - The palladium-catalysed four-component coupling of a halide, terminal alkyne, molybdenum hexacarbonyl and either a hydrazine or amidine has been shown to be an efficient method for the construction of highly substituted pyrazoles and pyrimidines, respectively, in a one-pot process

KW - carbonylations

KW - combinatorial chemistry

KW - heterocycles

KW - multicomponent reactions

KW - palladium

U2 - 10.1055/s-2007-1000839

DO - 10.1055/s-2007-1000839

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Access to Document

10.1055/s-2007-1000839