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Abstract
In this paper we present a model of drug release from a drug eluting-stent and the subsequent drug transport in the arterial wall. In order to study the complete process, a two-phase mathematical model describing the transport of a drug between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes both the solid-liquid transfer (dissolution) and diffusion processes in the polymeric substrate as well as diffusion, convection and reaction in the tissue layer. We adopt a semi-analytical approach in solving the four resulting equations. The model serves as a useful tool for providing insight into the influence of solid-liquid mass transfer in drug-eluting stent systems.
| Original language | English |
|---|---|
| Pages (from-to) | 47-56 |
| Number of pages | 13 |
| Journal | Journal of Coupled Systems and Multiscale Dynamics |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 2015 |
Keywords
- drug-eluting stents
- drug delivery
- solid-liquid mass transfer
- reaction-diffusion-convection equations
- two-phase model
- coupled partial differential equations
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Dive into the research topics of 'On the influence of solid-liquid mass transfer in the modelling of drug release from stents'. Together they form a unique fingerprint.Projects
- 1 Finished
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Optimal design of drug-eluting stents
McGinty, S. (Co-investigator), McKee, S. (Principal Investigator), McCormick, C. (Research Co-investigator), Wheel, M. (Research Co-investigator), Kennedy, S. (Research Co-investigator), Oldroyd, K. G. (Research Co-investigator) & McKittrick, C. (Researcher)
1/04/12 → 31/07/15
Project: Research