On the influence of solid-liquid mass transfer in the modelling of drug release from stents

Sean McGinty, Giuseppe Pontrelli

Research output: Contribution to journalArticle

Abstract

In this paper we present a model of drug release from a drug eluting-stent and the subsequent drug transport in the arterial wall. In order to study the complete process, a two-phase mathematical model describing the transport of a drug between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes both the solid-liquid transfer (dissolution) and diffusion processes in the polymeric substrate as well as diffusion, convection and reaction in the tissue layer. We adopt a semi-analytical approach in solving the four resulting equations. The model serves as a useful tool for providing insight into the influence of solid-liquid mass transfer in drug-eluting stent systems.
Original languageEnglish
Pages (from-to)47-56
Number of pages13
JournalJournal of Coupled Systems and Multiscale Dynamics
Volume3
Issue number1
DOIs
Publication statusPublished - Apr 2015

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Keywords

  • drug-eluting stents
  • drug delivery
  • solid-liquid mass transfer
  • reaction-diffusion-convection equations
  • two-phase model
  • coupled partial differential equations

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