Projects per year
Abstract
In this paper we present a model of drug release from a drug eluting-stent and the subsequent drug transport in the arterial wall. In order to study the complete process, a two-phase mathematical model describing the transport of a drug between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes both the solid-liquid transfer (dissolution) and diffusion processes in the polymeric substrate as well as diffusion, convection and reaction in the tissue layer. We adopt a semi-analytical approach in solving the four resulting equations. The model serves as a useful tool for providing insight into the influence of solid-liquid mass transfer in drug-eluting stent systems.
Original language | English |
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Pages (from-to) | 47-56 |
Number of pages | 13 |
Journal | Journal of Coupled Systems and Multiscale Dynamics |
Volume | 3 |
Issue number | 1 |
DOIs | |
Publication status | Published - Apr 2015 |
Keywords
- drug-eluting stents
- drug delivery
- solid-liquid mass transfer
- reaction-diffusion-convection equations
- two-phase model
- coupled partial differential equations
Projects
- 1 Finished
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Optimal design of drug-eluting stents
McGinty, S., McKee, S., McCormick, C., Wheel, M., Kennedy, S., Oldroyd, K. G. & McKittrick, C.
1/04/12 → 31/07/15
Project: Research