On deriving a hybrid model for carbohydrate uptake in escherichia coli

Eric Bullinger, T. Sauter, F. Allgöwer, E.D. Gilles

Research output: Contribution to conferencePaper

1 Citation (Scopus)

Abstract

In the past years, several large dynamical models of cellular metabolism have been published. Even more are going to come on the way towards models of the complete cellular metabolism. As the models are nonlinear, analyzing and understanding them is a not trivial task. This paper proposes a method to finding approximate models that explicitly take into account the switching behavior inherently present in several parts of the cellular metabolism. First, the states are separated into functional units based on similar "activity" along suitable trajectories. Important are the choices of sufficiently stimulating trajectories and of when a state is called active. Secondly, an automata model is build using the result of the first step. A model of carbohydrate uptake and the glycolysis is used to demonstrate the feasibility of the proposed method.
Original languageEnglish
DOIs
Publication statusPublished - Jul 2002
Event15th Triennial World Congress of the International Federation of Automatic Control - Barcelona, Spain
Duration: 21 Jul 200226 Jul 2002

Conference

Conference15th Triennial World Congress of the International Federation of Automatic Control
CountrySpain
CityBarcelona
Period21/07/0226/07/02

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Keywords

  • deriving
  • hybrid model
  • carbohydrate uptake
  • escherichia coli
  • model reduction
  • biochemical modeling
  • hybrid system

Cite this

Bullinger, E., Sauter, T., Allgöwer, F., & Gilles, E. D. (2002). On deriving a hybrid model for carbohydrate uptake in escherichia coli. Paper presented at 15th Triennial World Congress of the International Federation of Automatic Control, Barcelona, Spain. https://doi.org/10.3182/20020721-6-ES-1901.01312