Abstract
Three-dimensional (3D) multicellular spheroids have been identified as a suitable model of solid tumours for drug screening and cancer research [1]. However, creating and monitoring a large number of spheroids using conventional methods remains labour-intensive. This work reports a novel double-layer microfluidic device for the generation and culture of 3D multicellular spheroids and its use with biopsy samples. The system enables drug concentration-response curves to be obtained from a limited amount of sample material by applying a drug concentration gradient using an integrated passive microchannel network.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) |
| Place of Publication | San Diego, CA |
| Pages | 577-578 |
| Number of pages | 2 |
| Publication status | Published - 9 Oct 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Convention Center Dublin, Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016 http://www.microtas2016.org/ |
Conference
| Conference | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|---|
| Abbreviated title | MicroTas 2016 |
| Country | Ireland |
| City | Dublin |
| Period | 9/10/16 → 13/10/16 |
| Internet address |
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Keywords
- spheroid tumour
- drug-screening
- cancer research
- microfluidic device
- 3D multicellular spheroids
- biopsy samples
Cite this
Christ, T., Payne, S., Yan, Y., Ren, J., Edwards, J., Boyd, M., & Zagnoni, M. (2016). On-chip formation of 3D spheroids for patient-derived tissue screening. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) (pp. 577-578). San Diego, CA.