On-chip formation of 3D spheroids for patient-derived tissue screening

T. Christ, S. Payne, Y. Yan, J. Ren, J. Edwards, M. Boyd, M. Zagnoni

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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Abstract

Three-dimensional (3D) multicellular spheroids have been identified as a suitable model of solid tumours for drug screening and cancer research [1]. However, creating and monitoring a large number of spheroids using conventional methods remains labour-intensive. This work reports a novel double-layer microfluidic device for the generation and culture of 3D multicellular spheroids and its use with biopsy samples. The system enables drug concentration-response curves to be obtained from a limited amount of sample material by applying a drug concentration gradient using an integrated passive microchannel network.
Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Place of PublicationSan Diego, CA
Pages577-578
Number of pages2
Publication statusPublished - 9 Oct 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Convention Center Dublin, Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016
http://www.microtas2016.org/

Conference

Conference20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated titleMicroTas 2016
CountryIreland
CityDublin
Period9/10/1613/10/16
Internet address

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Keywords

  • spheroid tumour
  • drug-screening
  • cancer research
  • microfluidic device
  • 3D multicellular spheroids
  • biopsy samples

Cite this

Christ, T., Payne, S., Yan, Y., Ren, J., Edwards, J., Boyd, M., & Zagnoni, M. (2016). On-chip formation of 3D spheroids for patient-derived tissue screening. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) (pp. 577-578). San Diego, CA.