Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals

A J Anderson, A L Harvey

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Release of acetylcholine at the neuromuscular junctions of skeletal muscle is not sensitive to organic Ca2+ channel blockers. However, in mouse motor nerve endings, extracellular recording reveals that a verapamil-sensitive Ca2+ current can be induced after block of K+ channels. Recordings of extracellular action potentials from inside the perineural sheaths of nerves innervating mouse triangularis sterni muscles reveal that this verapamil-sensitive current is not blocked by omega-conotoxin, and hence, it does not involve channels similar to the L-channels of neuronal cell bodies.
Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalNeuroscience Letters
Volume82
Issue number2
DOIs
Publication statusPublished - 23 Nov 1987

Keywords

  • animals
  • anura
  • calcium
  • ion channels
  • male
  • mice
  • inbred BALB C mice
  • mollusk venoms
  • nerve block
  • neuromuscular junction
  • verapamil
  • omega-conotoxins

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