Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals

A J Anderson, A L Harvey

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Release of acetylcholine at the neuromuscular junctions of skeletal muscle is not sensitive to organic Ca2+ channel blockers. However, in mouse motor nerve endings, extracellular recording reveals that a verapamil-sensitive Ca2+ current can be induced after block of K+ channels. Recordings of extracellular action potentials from inside the perineural sheaths of nerves innervating mouse triangularis sterni muscles reveal that this verapamil-sensitive current is not blocked by omega-conotoxin, and hence, it does not involve channels similar to the L-channels of neuronal cell bodies.
Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalNeuroscience Letters
Volume82
Issue number2
DOIs
Publication statusPublished - 23 Nov 1987

Fingerprint

omega-Conotoxins
Calcium Channels
Verapamil
Nerve Endings
Neuromuscular Junction
Action Potentials
Acetylcholine
Skeletal Muscle
Muscles
Cell Body

Keywords

  • animals
  • anura
  • calcium
  • ion channels
  • male
  • mice
  • inbred BALB C mice
  • mollusk venoms
  • nerve block
  • neuromuscular junction
  • verapamil
  • omega-conotoxins

Cite this

@article{617984c8c482495482abb0335254446c,
title = "Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals",
abstract = "Release of acetylcholine at the neuromuscular junctions of skeletal muscle is not sensitive to organic Ca2+ channel blockers. However, in mouse motor nerve endings, extracellular recording reveals that a verapamil-sensitive Ca2+ current can be induced after block of K+ channels. Recordings of extracellular action potentials from inside the perineural sheaths of nerves innervating mouse triangularis sterni muscles reveal that this verapamil-sensitive current is not blocked by omega-conotoxin, and hence, it does not involve channels similar to the L-channels of neuronal cell bodies.",
keywords = "animals, anura, calcium, ion channels, male, mice, inbred BALB C mice, mollusk venoms, nerve block, neuromuscular junction, verapamil, omega-conotoxins",
author = "Anderson, {A J} and Harvey, {A L}",
year = "1987",
month = "11",
day = "23",
doi = "10.1016/0304-3940(87)90125-X",
language = "English",
volume = "82",
pages = "177--180",
journal = "Neuroscience Letters",
issn = "0304-3940",
number = "2",

}

Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals. / Anderson, A J; Harvey, A L.

In: Neuroscience Letters, Vol. 82, No. 2, 23.11.1987, p. 177-180.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals

AU - Anderson, A J

AU - Harvey, A L

PY - 1987/11/23

Y1 - 1987/11/23

N2 - Release of acetylcholine at the neuromuscular junctions of skeletal muscle is not sensitive to organic Ca2+ channel blockers. However, in mouse motor nerve endings, extracellular recording reveals that a verapamil-sensitive Ca2+ current can be induced after block of K+ channels. Recordings of extracellular action potentials from inside the perineural sheaths of nerves innervating mouse triangularis sterni muscles reveal that this verapamil-sensitive current is not blocked by omega-conotoxin, and hence, it does not involve channels similar to the L-channels of neuronal cell bodies.

AB - Release of acetylcholine at the neuromuscular junctions of skeletal muscle is not sensitive to organic Ca2+ channel blockers. However, in mouse motor nerve endings, extracellular recording reveals that a verapamil-sensitive Ca2+ current can be induced after block of K+ channels. Recordings of extracellular action potentials from inside the perineural sheaths of nerves innervating mouse triangularis sterni muscles reveal that this verapamil-sensitive current is not blocked by omega-conotoxin, and hence, it does not involve channels similar to the L-channels of neuronal cell bodies.

KW - animals

KW - anura

KW - calcium

KW - ion channels

KW - male

KW - mice

KW - inbred BALB C mice

KW - mollusk venoms

KW - nerve block

KW - neuromuscular junction

KW - verapamil

KW - omega-conotoxins

U2 - 10.1016/0304-3940(87)90125-X

DO - 10.1016/0304-3940(87)90125-X

M3 - Article

VL - 82

SP - 177

EP - 180

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -