Projects per year
Abstract
A range of minor groove binders (MGBs) and the intermediates formed in their synthesis was screened against infectious agents including bacteria and parasites. Activity was found against Trypanosoma brucei. Of particular interest is a molecule which does not contain a typical basic flexible tail group found in MGBs, but instead has an unprotected carboxylic acid group at that position (compound 4), which has activity of 63 nM against T. brucei.
Original language | English |
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Pages (from-to) | 1170-1179 |
Number of pages | 10 |
Journal | Medicinal Chemistry Research |
Volume | 23 |
Issue number | 3 |
Early online date | 28 Aug 2013 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- DNA
- minor groove binder
- amide
- thiazole
- anti-parasitic activity
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Dive into the research topics of 'Oligoamides of 2-amino-5-alkylthiazole 4-carboxylic acids: anti-trypanosomal compounds'. Together they form a unique fingerprint.Profiles
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Simon MacKay
Person: Academic
Projects
- 1 Finished
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SMSdrug.net: Alignment Of Synthesis, Medicinal Chemistry And Strucrural Genomics To Accelerate Uk Drug Discovery: Network SMS-Drug
Tomkinson, N., C. Bagley, M., Feilden, H., Johnston, B., Knapp, S., MacKay, S., Overington, J. & Spencer, J.
EPSRC (Engineering and Physical Sciences Research Council)
1/09/11 → 31/08/15
Project: Research