Off-label use of pentazocine and the associated adverse events among pediatric surgical patients in a tertiary hospital in Northern Nigeria: a retrospective chart review

Kazeem A. Oshikoya, Ibrahim Abayomi Ogunyinka, Brian Godman

Research output: Contribution to journalArticle

Abstract

Background and aims: Pentazocine remains a widely used opioid pre-anesthetic medication and post-operative analgesic in low- and middle-income countries despite concerns. We assessed the adverse events (AEs) associated with off-label use of pentazocine in pediatric surgical patients and determined the possible risk factors associated with slow respiratory AEs. Method: Children ≤18 years old were administered pentazocine IM/IV as a pre-anesthetic medication or post-operative analgesic. Pertinent data including total daily dose and duration of use of pentazocine and its associated AEs were obtained from patients’ case files. Risk factors associated with slow respiratory AEs were determined using logistic regression analyses. Results: One hundred and fifty-nine patients were included with a median age of 2 years; they were mainly males (52.8%). Pentazocine was administered off-label to all patients for post-operative pain management (96.2%) or pre-anesthetic medication (3.8%). All patients experienced at least one AE with most experiencing 2–7 AEs. Rapid breathing (120; 18.7%), followed by fast pulse (101; 15.7%) and sleepiness/sedation/drowsiness (81; 12.6%) were the most common AEs. None of the demographics and clinical variables significantly predicted the risk of slow respiratory AEs. Conclusion: Off-label use of pentazocine is common and associated with multiple AEs. Care is needed as no predictors of slow respiratory AEs were observed.

LanguageEnglish
Pages1505-1512
Number of pages8
JournalCurrent Medical Research and Opinion
Volume35
Issue number9
Early online date5 Mar 2019
DOIs
Publication statusPublished - 8 Apr 2019

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Off-Label Use
Pentazocine
Nigeria
Tertiary Care Centers
Pediatrics
Anesthetics
Analgesics
Sleep Stages
Pain Management
Opioid Analgesics
Respiration
Logistic Models
Regression Analysis
Demography

Keywords

  • off-label
  • pentazocine
  • surgery
  • Nigeria

Cite this

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title = "Off-label use of pentazocine and the associated adverse events among pediatric surgical patients in a tertiary hospital in Northern Nigeria: a retrospective chart review",
abstract = "Background and aims: Pentazocine remains a widely used opioid pre-anesthetic medication and post-operative analgesic in low- and middle-income countries despite concerns. We assessed the adverse events (AEs) associated with off-label use of pentazocine in pediatric surgical patients and determined the possible risk factors associated with slow respiratory AEs. Method: Children ≤18 years old were administered pentazocine IM/IV as a pre-anesthetic medication or post-operative analgesic. Pertinent data including total daily dose and duration of use of pentazocine and its associated AEs were obtained from patients’ case files. Risk factors associated with slow respiratory AEs were determined using logistic regression analyses. Results: One hundred and fifty-nine patients were included with a median age of 2 years; they were mainly males (52.8{\%}). Pentazocine was administered off-label to all patients for post-operative pain management (96.2{\%}) or pre-anesthetic medication (3.8{\%}). All patients experienced at least one AE with most experiencing 2–7 AEs. Rapid breathing (120; 18.7{\%}), followed by fast pulse (101; 15.7{\%}) and sleepiness/sedation/drowsiness (81; 12.6{\%}) were the most common AEs. None of the demographics and clinical variables significantly predicted the risk of slow respiratory AEs. Conclusion: Off-label use of pentazocine is common and associated with multiple AEs. Care is needed as no predictors of slow respiratory AEs were observed.",
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Off-label use of pentazocine and the associated adverse events among pediatric surgical patients in a tertiary hospital in Northern Nigeria : a retrospective chart review. / Oshikoya, Kazeem A.; Ogunyinka, Ibrahim Abayomi ; Godman, Brian.

In: Current Medical Research and Opinion, Vol. 35, No. 9, 08.04.2019, p. 1505-1512.

Research output: Contribution to journalArticle

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