Ocular toxoplasmosis: in the storm of the eye

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48 Citations (Scopus)

Abstract

Ocular toxoplasmosis (OT) can occur in the children of mothers infected with Toxoplasma gondii during pregnancy. It is not limited to the congenitally infected, but can also occur following adult-acquired infection or as a result of disease reactivation in immune-compromised and pregnant individuals. Many aspects of immune privilege in the eye, including constitutive TGF-β expression and reduced MHC class 1 expression, would appear at first to favour parasite survival. Conversely, many of the mechanisms that control parasite multiplication in other anatomical sites, such as nitric oxide expression, IFN-γ and TNF-α, are known to disrupt immune privilege and are associated with ocular damage. Taking into account the opposing needs of limiting parasite multiplication and minimizing tissue destruction we review the pathogenesis of OT in the murine model.
Original languageEnglish
Pages (from-to)635-642
Number of pages8
JournalParasite Immunology
Volume28
Issue number12
DOIs
Publication statusPublished - Dec 2006

Keywords

  • immune privilege
  • immunopathology
  • ocular toxoplasmosis
  • pharmacology
  • toxoplasma

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