Obesity and metabolic syndrome in adolescent survivors of standard risk childhood acute lymphoblastic leukemia in Saudi Arabia

Fahad Aldhafiri, Abdallah Al-Nasser, Abdulaziz Al-Sugair, Hanan Al-Mutairi, David Young, John J Reilly

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

This study estimated prevalence of unhealthy
weight status and metabolic syndrome (MS) amongst Saudi survivors of standard risk ALL. Procedure. We recruited 56 survivors,
mean age 13.4 years (SD 4.1), a mean of 9.1 years (SD 4.1) postdiagnosis. The BMI for age was used to define weight status relative
to national (Saudi) and international (Cole et al., Cole-IOTF, WHO,
and CDC) reference data. We measured body composition by dualenergy X-ray absorptiometry (DXA), waist circumference, blood
pressure, lipid profile (HDL-C, Triglycerides), fasting glucose and
insulin. Results. According to international definitions based on
BMI for age, around half of the sample had unhealthy weight status.
All of the approaches based on BMI for age underestimated overfatness, present in 27/51 (53%) of the sample according to DXA.
Prevalence of MS was 7.1% (3/42 of those over 9-years old) and
5.4% (3/56) by applying the International Diabetes Federation (IDF)
definition and National Cholesterol Education Program Third Adult
Treatment panel Guidelines (NCEP III), respectively. However, MS
by the NCEP III definition was present in 19% of the overweight and
obese survivors and 7.1% of the sample had at least two of the
components of MS. Conclusion. Unhealthy body weight and overfatness may be common amongst adolescent Saudi survivors of
standard risk ALL, though overweight and obesity may be no
more common than in the general Saudi adolescent population.
Defining weight status using BMI underestimates overfatness.
Ideally, body composition and cardiometabolic risk factors should
be monitored at late effects clinics. Pediatr Blood Cancer 2012;59:
133–137. 2011 Wiley Periodicals, Inc.
LanguageEnglish
Pages133-137
Number of pages5
JournalPediatric Blood and Cancer
Volume59
Issue number1
Early online date11 Dec 2011
DOIs
Publication statusPublished - 15 Jul 2012

Fingerprint

Saudi Arabia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survivors
Obesity
Photon Absorptiometry
Body Composition
Weights and Measures
Waist Circumference
Centers for Disease Control and Prevention (U.S.)
Fasting
Triglycerides
Cross-Sectional Studies
Cholesterol
Body Weight
Guidelines
Lipids
Education
Glucose
Population
Neoplasms

Keywords

  • acute lymphoblastic leukemia
  • obesity
  • metabolic syndrome
  • adolescent survivors
  • saudi arabia
  • standard risk
  • late effects

Cite this

Aldhafiri, Fahad ; Al-Nasser, Abdallah ; Al-Sugair, Abdulaziz ; Al-Mutairi, Hanan ; Young, David ; Reilly, John J. / Obesity and metabolic syndrome in adolescent survivors of standard risk childhood acute lymphoblastic leukemia in Saudi Arabia. In: Pediatric Blood and Cancer. 2012 ; Vol. 59, No. 1. pp. 133-137.
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abstract = "This study estimated prevalence of unhealthyweight status and metabolic syndrome (MS) amongst Saudi survivors of standard risk ALL. Procedure. We recruited 56 survivors,mean age 13.4 years (SD 4.1), a mean of 9.1 years (SD 4.1) postdiagnosis. The BMI for age was used to define weight status relativeto national (Saudi) and international (Cole et al., Cole-IOTF, WHO,and CDC) reference data. We measured body composition by dualenergy X-ray absorptiometry (DXA), waist circumference, bloodpressure, lipid profile (HDL-C, Triglycerides), fasting glucose andinsulin. Results. According to international definitions based onBMI for age, around half of the sample had unhealthy weight status.All of the approaches based on BMI for age underestimated overfatness, present in 27/51 (53{\%}) of the sample according to DXA.Prevalence of MS was 7.1{\%} (3/42 of those over 9-years old) and5.4{\%} (3/56) by applying the International Diabetes Federation (IDF)definition and National Cholesterol Education Program Third AdultTreatment panel Guidelines (NCEP III), respectively. However, MSby the NCEP III definition was present in 19{\%} of the overweight andobese survivors and 7.1{\%} of the sample had at least two of thecomponents of MS. Conclusion. Unhealthy body weight and overfatness may be common amongst adolescent Saudi survivors ofstandard risk ALL, though overweight and obesity may be nomore common than in the general Saudi adolescent population.Defining weight status using BMI underestimates overfatness.Ideally, body composition and cardiometabolic risk factors shouldbe monitored at late effects clinics. Pediatr Blood Cancer 2012;59:133–137. 2011 Wiley Periodicals, Inc.",
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Obesity and metabolic syndrome in adolescent survivors of standard risk childhood acute lymphoblastic leukemia in Saudi Arabia. / Aldhafiri, Fahad; Al-Nasser, Abdallah; Al-Sugair, Abdulaziz; Al-Mutairi, Hanan; Young, David; Reilly, John J.

In: Pediatric Blood and Cancer, Vol. 59, No. 1, 15.07.2012, p. 133-137.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Obesity and metabolic syndrome in adolescent survivors of standard risk childhood acute lymphoblastic leukemia in Saudi Arabia

AU - Aldhafiri, Fahad

AU - Al-Nasser, Abdallah

AU - Al-Sugair, Abdulaziz

AU - Al-Mutairi, Hanan

AU - Young, David

AU - Reilly, John J

PY - 2012/7/15

Y1 - 2012/7/15

N2 - This study estimated prevalence of unhealthyweight status and metabolic syndrome (MS) amongst Saudi survivors of standard risk ALL. Procedure. We recruited 56 survivors,mean age 13.4 years (SD 4.1), a mean of 9.1 years (SD 4.1) postdiagnosis. The BMI for age was used to define weight status relativeto national (Saudi) and international (Cole et al., Cole-IOTF, WHO,and CDC) reference data. We measured body composition by dualenergy X-ray absorptiometry (DXA), waist circumference, bloodpressure, lipid profile (HDL-C, Triglycerides), fasting glucose andinsulin. Results. According to international definitions based onBMI for age, around half of the sample had unhealthy weight status.All of the approaches based on BMI for age underestimated overfatness, present in 27/51 (53%) of the sample according to DXA.Prevalence of MS was 7.1% (3/42 of those over 9-years old) and5.4% (3/56) by applying the International Diabetes Federation (IDF)definition and National Cholesterol Education Program Third AdultTreatment panel Guidelines (NCEP III), respectively. However, MSby the NCEP III definition was present in 19% of the overweight andobese survivors and 7.1% of the sample had at least two of thecomponents of MS. Conclusion. Unhealthy body weight and overfatness may be common amongst adolescent Saudi survivors ofstandard risk ALL, though overweight and obesity may be nomore common than in the general Saudi adolescent population.Defining weight status using BMI underestimates overfatness.Ideally, body composition and cardiometabolic risk factors shouldbe monitored at late effects clinics. Pediatr Blood Cancer 2012;59:133–137. 2011 Wiley Periodicals, Inc.

AB - This study estimated prevalence of unhealthyweight status and metabolic syndrome (MS) amongst Saudi survivors of standard risk ALL. Procedure. We recruited 56 survivors,mean age 13.4 years (SD 4.1), a mean of 9.1 years (SD 4.1) postdiagnosis. The BMI for age was used to define weight status relativeto national (Saudi) and international (Cole et al., Cole-IOTF, WHO,and CDC) reference data. We measured body composition by dualenergy X-ray absorptiometry (DXA), waist circumference, bloodpressure, lipid profile (HDL-C, Triglycerides), fasting glucose andinsulin. Results. According to international definitions based onBMI for age, around half of the sample had unhealthy weight status.All of the approaches based on BMI for age underestimated overfatness, present in 27/51 (53%) of the sample according to DXA.Prevalence of MS was 7.1% (3/42 of those over 9-years old) and5.4% (3/56) by applying the International Diabetes Federation (IDF)definition and National Cholesterol Education Program Third AdultTreatment panel Guidelines (NCEP III), respectively. However, MSby the NCEP III definition was present in 19% of the overweight andobese survivors and 7.1% of the sample had at least two of thecomponents of MS. Conclusion. Unhealthy body weight and overfatness may be common amongst adolescent Saudi survivors ofstandard risk ALL, though overweight and obesity may be nomore common than in the general Saudi adolescent population.Defining weight status using BMI underestimates overfatness.Ideally, body composition and cardiometabolic risk factors shouldbe monitored at late effects clinics. Pediatr Blood Cancer 2012;59:133–137. 2011 Wiley Periodicals, Inc.

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KW - obesity

KW - metabolic syndrome

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KW - saudi arabia

KW - standard risk

KW - late effects

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