Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI

C. Ross Ethier; Peter D. Weinberg; Willy Gsell; Jordi L. Tremoleda; Mark Van Doormaal; Yvette Bohraus; Marzena Wylezinska; Asimina Kazakidi

doi:10.1115/SBC2010-19270

Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI

C. Ross Ethier, Peter D. Weinberg, Willy Gsell, Jordi L. Tremoleda, Mark Van Doormaal, Yvette Bohraus, Marzena Wylezinska, Asimina Kazakidi

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Abstract

Atherosclerotic lesions have a highly non-uniform distribution in regions of arterial branching and curvature, consistent with hemodynamic factors, in particular wall shear stress (WSS), controlling their development. The widespread and increasing use of the mouse as a model for studying atherosclerosis has encouraged investigation of the hemodynamics of the mouse aortic arch [1–3], in which previous studies have revealed areas of high and low lesion prevalence and variation in the expression of pro-atherogenic molecules [4]. Our previous computational simulations [1–2] did not produce distributions of WSS that explain the pattern of lesions. We are currently investigating whether incorporation of more realistic aortic root velocity measurements, obtained using phase-contrast magnetic resonance imaging (PC-MRI), into these simulations can improve the correlation with disease. Here we present velocities obtained by PC-MRI and preliminary simulations employing the data.

Original language	English
Title of host publication	ASME 2010 Summer Bioengineering Conference, SBC 2010
Place of Publication	New York, NY
Pages	555-556
Number of pages	2
DOIs	https://doi.org/10.1115/SBC2010-19270
Publication status	Published - 2010
Event	ASME 2010 Summer Bioengineering Conference, SBC 2010 - Naples, FL, United States Duration: 16 Jun 2010 → 19 Jun 2010

Conference

Conference	ASME 2010 Summer Bioengineering Conference, SBC 2010
Country/Territory	United States
City	Naples, FL
Period	16/06/10 → 19/06/10

Keywords

modeling
magnetic resonance imaging
blood flow
inflow
aortic arch

Access to Document

10.1115/SBC2010-19270

Cite this

@inproceedings{5c8aff97acbe451693a714b7a7bd1aed,

title = "Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI",

abstract = "Atherosclerotic lesions have a highly non-uniform distribution in regions of arterial branching and curvature, consistent with hemodynamic factors, in particular wall shear stress (WSS), controlling their development. The widespread and increasing use of the mouse as a model for studying atherosclerosis has encouraged investigation of the hemodynamics of the mouse aortic arch [1–3], in which previous studies have revealed areas of high and low lesion prevalence and variation in the expression of pro-atherogenic molecules [4]. Our previous computational simulations [1–2] did not produce distributions of WSS that explain the pattern of lesions. We are currently investigating whether incorporation of more realistic aortic root velocity measurements, obtained using phase-contrast magnetic resonance imaging (PC-MRI), into these simulations can improve the correlation with disease. Here we present velocities obtained by PC-MRI and preliminary simulations employing the data.",

keywords = "modeling, magnetic resonance imaging, blood flow, inflow, aortic arch",

author = "Ethier, {C. Ross} and Weinberg, {Peter D.} and Willy Gsell and Tremoleda, {Jordi L.} and {Van Doormaal}, Mark and Yvette Bohraus and Marzena Wylezinska and Asimina Kazakidi",

year = "2010",

doi = "10.1115/SBC2010-19270",

language = "English",

isbn = "9780791844038",

pages = "555--556",

booktitle = "ASME 2010 Summer Bioengineering Conference, SBC 2010",

note = "ASME 2010 Summer Bioengineering Conference, SBC 2010 ; Conference date: 16-06-2010 Through 19-06-2010",

}

Ethier, CR, Weinberg, PD, Gsell, W, Tremoleda, JL, Van Doormaal, M, Bohraus, Y, Wylezinska, M & Kazakidi, A 2010, Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI. in ASME 2010 Summer Bioengineering Conference, SBC 2010. New York, NY, pp. 555-556, ASME 2010 Summer Bioengineering Conference, SBC 2010, Naples, FL, United States, 16/06/10. https://doi.org/10.1115/SBC2010-19270

TY - GEN

T1 - Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI

AU - Ethier, C. Ross

AU - Weinberg, Peter D.

AU - Gsell, Willy

AU - Tremoleda, Jordi L.

AU - Van Doormaal, Mark

AU - Bohraus, Yvette

AU - Wylezinska, Marzena

AU - Kazakidi, Asimina

PY - 2010

Y1 - 2010

N2 - Atherosclerotic lesions have a highly non-uniform distribution in regions of arterial branching and curvature, consistent with hemodynamic factors, in particular wall shear stress (WSS), controlling their development. The widespread and increasing use of the mouse as a model for studying atherosclerosis has encouraged investigation of the hemodynamics of the mouse aortic arch [1–3], in which previous studies have revealed areas of high and low lesion prevalence and variation in the expression of pro-atherogenic molecules [4]. Our previous computational simulations [1–2] did not produce distributions of WSS that explain the pattern of lesions. We are currently investigating whether incorporation of more realistic aortic root velocity measurements, obtained using phase-contrast magnetic resonance imaging (PC-MRI), into these simulations can improve the correlation with disease. Here we present velocities obtained by PC-MRI and preliminary simulations employing the data.

AB - Atherosclerotic lesions have a highly non-uniform distribution in regions of arterial branching and curvature, consistent with hemodynamic factors, in particular wall shear stress (WSS), controlling their development. The widespread and increasing use of the mouse as a model for studying atherosclerosis has encouraged investigation of the hemodynamics of the mouse aortic arch [1–3], in which previous studies have revealed areas of high and low lesion prevalence and variation in the expression of pro-atherogenic molecules [4]. Our previous computational simulations [1–2] did not produce distributions of WSS that explain the pattern of lesions. We are currently investigating whether incorporation of more realistic aortic root velocity measurements, obtained using phase-contrast magnetic resonance imaging (PC-MRI), into these simulations can improve the correlation with disease. Here we present velocities obtained by PC-MRI and preliminary simulations employing the data.

KW - modeling

KW - magnetic resonance imaging

KW - blood flow

KW - inflow

KW - aortic arch

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U2 - 10.1115/SBC2010-19270

DO - 10.1115/SBC2010-19270

M3 - Conference contribution book

AN - SCOPUS:84893809517

SN - 9780791844038

SP - 555

EP - 556

BT - ASME 2010 Summer Bioengineering Conference, SBC 2010

CY - New York, NY

T2 - ASME 2010 Summer Bioengineering Conference, SBC 2010

Y2 - 16 June 2010 through 19 June 2010

ER -

Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI

Abstract

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Correlation of mouse aortic arch hemodynamics with endothelial transcription factor expression and activity

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Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI

Abstract

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Keywords

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Correlation of mouse aortic arch hemodynamics with endothelial transcription factor expression and activity

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