Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI

C. Ross Ethier, Peter D. Weinberg, Willy Gsell, Jordi L. Tremoleda, Mark Van Doormaal, Yvette Bohraus, Marzena Wylezinska, Asimina Kazakidi

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

Atherosclerotic lesions have a highly non-uniform distribution in regions of arterial branching and curvature, consistent with hemodynamic factors, in particular wall shear stress (WSS), controlling their development. The widespread and increasing use of the mouse as a model for studying atherosclerosis has encouraged investigation of the hemodynamics of the mouse aortic arch [1–3], in which previous studies have revealed areas of high and low lesion prevalence and variation in the expression of pro-atherogenic molecules [4]. Our previous computational simulations [1–2] did not produce distributions of WSS that explain the pattern of lesions. We are currently investigating whether incorporation of more realistic aortic root velocity measurements, obtained using phase-contrast magnetic resonance imaging (PC-MRI), into these simulations can improve the correlation with disease. Here we present velocities obtained by PC-MRI and preliminary simulations employing the data.
Original languageEnglish
Title of host publicationASME 2010 Summer Bioengineering Conference, SBC 2010
Place of PublicationNew York, NY
Pages555-556
Number of pages2
DOIs
Publication statusPublished - 2010
EventASME 2010 Summer Bioengineering Conference, SBC 2010 - Naples, FL, United States
Duration: 16 Jun 201019 Jun 2010

Conference

ConferenceASME 2010 Summer Bioengineering Conference, SBC 2010
CountryUnited States
CityNaples, FL
Period16/06/1019/06/10

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Keywords

  • modeling
  • magnetic resonance imaging
  • blood flow
  • inflow
  • aortic arch

Cite this

Ethier, C. R., Weinberg, P. D., Gsell, W., Tremoleda, J. L., Van Doormaal, M., Bohraus, Y., ... Kazakidi, A. (2010). Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI. In ASME 2010 Summer Bioengineering Conference, SBC 2010 (pp. 555-556). New York, NY. https://doi.org/10.1115/SBC2010-19270