Projects per year
Abstract
Atherosclerotic lesions have a highly non-uniform distribution in regions of arterial branching and curvature, consistent with hemodynamic factors, in particular wall shear stress (WSS), controlling their development. The widespread and increasing use of the mouse as a model for studying atherosclerosis has encouraged investigation of the hemodynamics of the mouse aortic arch [1–3], in which previous studies have revealed areas of high and low lesion prevalence and variation in the expression of pro-atherogenic molecules [4]. Our previous computational simulations [1–2] did not produce distributions of WSS that explain the pattern of lesions. We are currently investigating whether incorporation of more realistic aortic root velocity measurements, obtained using phase-contrast magnetic resonance imaging (PC-MRI), into these simulations can improve the correlation with disease. Here we present velocities obtained by PC-MRI and preliminary simulations employing the data.
Original language | English |
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Title of host publication | ASME 2010 Summer Bioengineering Conference, SBC 2010 |
Place of Publication | New York, NY |
Pages | 555-556 |
Number of pages | 2 |
DOIs | |
Publication status | Published - 2010 |
Event | ASME 2010 Summer Bioengineering Conference, SBC 2010 - Naples, FL, United States Duration: 16 Jun 2010 → 19 Jun 2010 |
Conference
Conference | ASME 2010 Summer Bioengineering Conference, SBC 2010 |
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Country/Territory | United States |
City | Naples, FL |
Period | 16/06/10 → 19/06/10 |
Keywords
- modeling
- magnetic resonance imaging
- blood flow
- inflow
- aortic arch
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Dive into the research topics of 'Numerical modelling of blood flow in the mouse aortic arch using inflow velocities obtained by phase-contrast MRI'. Together they form a unique fingerprint.Projects
- 1 Finished
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Correlation of mouse aortic arch hemodynamics with endothelial transcription factor expression and activity
Ethier, C. R. (Principal Investigator), Mason, J. (Principal Investigator), Gsell, W. (Principal Investigator), Weinberg, P. D. (Principal Investigator) & Kazakidi, A. (Principal Investigator)
1/04/09 → 1/12/09
Project: Projects from Previous Employment