Numerical analysis of collagen injection to the striatum

I.M. Syntouka; P.E. Riches; A. Kazakidi

Numerical analysis of collagen injection to the striatum

I.M. Syntouka, P.E. Riches, A. Kazakidi

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

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Abstract

Parkinson’s disease (PD) is a degenerative disorder that affects dopaminergic neurons in the substantia nigra. In PD, the dopaminergic neurons degenerate, resulting in less dopamine being available for neurotransmission. Cell therapy, along with the use of biomaterials, has emerged as a promising therapeutic strategy. However, the existing delivery approaches have shown limited success in clinical translation1. This study aims to develop a device for the delivery of a cell-embedded in situ forming collagen hydrogel. Here, computational approaches on the delivery of collagen to the striatum are presented, to gain insight into different parameters affecting the delivery.

Original language	English
Title of host publication	BioMedEng19 Proceedings
Place of Publication	London
Pages	197
Number of pages	1
Publication status	Published - 5 Sep 2019

Keywords

Parkinson's Disease
cell therapy
brain tissue
collagen injections

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Syntouka-etal-BioMedEng-2019-Numerical-analysis-of-collagen-injectionAccepted author manuscript, 74.3 KB

https://www.biomedeng19.com/

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1 Finished

Design and Development of a Delivery Device for an Injectable Collagen Scaffold by Computational and Experimental Analysis (ESR-15) for BrainMatTrain H2020 MSCA ITN ETN (676408)
Kazakidi, A.
Collagen Solutions PLC
1/09/17 → 31/08/20
Project: Research - Studentship

Cite this

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title = "Numerical analysis of collagen injection to the striatum",

abstract = "Parkinson{\textquoteright}s disease (PD) is a degenerative disorder that affects dopaminergic neurons in the substantia nigra. In PD, the dopaminergic neurons degenerate, resulting in less dopamine being available for neurotransmission. Cell therapy, along with the use of biomaterials, has emerged as a promising therapeutic strategy. However, the existing delivery approaches have shown limited success in clinical translation1. This study aims to develop a device for the delivery of a cell-embedded in situ forming collagen hydrogel. Here, computational approaches on the delivery of collagen to the striatum are presented, to gain insight into different parameters affecting the delivery.",

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AU - Syntouka, I.M.

AU - Riches, P.E.

AU - Kazakidi, A.

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N2 - Parkinson’s disease (PD) is a degenerative disorder that affects dopaminergic neurons in the substantia nigra. In PD, the dopaminergic neurons degenerate, resulting in less dopamine being available for neurotransmission. Cell therapy, along with the use of biomaterials, has emerged as a promising therapeutic strategy. However, the existing delivery approaches have shown limited success in clinical translation1. This study aims to develop a device for the delivery of a cell-embedded in situ forming collagen hydrogel. Here, computational approaches on the delivery of collagen to the striatum are presented, to gain insight into different parameters affecting the delivery.

AB - Parkinson’s disease (PD) is a degenerative disorder that affects dopaminergic neurons in the substantia nigra. In PD, the dopaminergic neurons degenerate, resulting in less dopamine being available for neurotransmission. Cell therapy, along with the use of biomaterials, has emerged as a promising therapeutic strategy. However, the existing delivery approaches have shown limited success in clinical translation1. This study aims to develop a device for the delivery of a cell-embedded in situ forming collagen hydrogel. Here, computational approaches on the delivery of collagen to the striatum are presented, to gain insight into different parameters affecting the delivery.

KW - Parkinson's Disease

KW - cell therapy

KW - brain tissue

KW - collagen injections

UR - https://www.biomedeng19.com/

M3 - Conference contribution book

SN - 978-1-9996465-2-3

SP - 197

BT - BioMedEng19 Proceedings

CY - London

ER -

Numerical analysis of collagen injection to the striatum

Abstract

Keywords

Access to Document

Design and Development of a Delivery Device for an Injectable Collagen Scaffold by Computational and Experimental Analysis (ESR-15) for BrainMatTrain H2020 MSCA ITN ETN (676408)

Cite this