Numerical analysis of collagen injection to the striatum

Parkinson’s disease (PD) is a degenerative disorder that affects dopaminergic neurons in the substantia nigra. In PD, the dopaminergic neurons degenerate, resulting in less dopamine being available for neurotransmission. Cell therapy, along with the use of biomaterials, has emerged as a promising therapeutic strategy. However, the existing delivery approaches have shown limited success in clinical translation1. This study aims to develop a device for the delivery of a cell-embedded in situ forming collagen hydrogel. Here, computational approaches on the delivery of collagen to the striatum are presented, to gain insight into different parameters affecting the delivery.