Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

J.A. Parkinson; P. Muller; B. Shroder; N.A. Kratochwil; R.A. Coxall; A. Parkin; S. Parsons; P.J. Sadler

doi:10.1002/anie.200390110

Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

J.A. Parkinson
, P. Muller
, B. Shroder
, N.A. Kratochwil
, R.A. Coxall
, A. Parkin
, S. Parsons
, P.J. Sadler

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.

Original language	English
Pages (from-to)	335-339
Number of pages	5
Journal	Angewandte Chemie- International Edition
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/anie.200390110
Publication status	Published - 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

photoreactions
novel platinum (IV) azide complexes
cancer cells
irradiation

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10.1002/anie.200390110

Cite this

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title = "Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes",

abstract = "Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.",

keywords = "photoreactions , novel platinum (IV) azide complexes , cancer cells, irradiation",

author = "J.A. Parkinson and P. Muller and B. Shroder and N.A. Kratochwil and R.A. Coxall and A. Parkin and S. Parsons and P.J. Sadler",

year = "2003",

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AU - Parkinson, J.A.

AU - Muller, P.

AU - Shroder, B.

AU - Kratochwil, N.A.

AU - Coxall, R.A.

AU - Parkin, A.

AU - Parsons, S.

AU - Sadler, P.J.

PY - 2003

Y1 - 2003

N2 - Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.

AB - Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.

KW - photoreactions

KW - novel platinum (IV) azide complexes

KW - cancer cells

KW - irradiation

U2 - 10.1002/anie.200390110

DO - 10.1002/anie.200390110

M3 - Article

SN - 1521-3773

VL - 42

SP - 335

EP - 339

JO - Angewandte Chemie- International Edition

JF - Angewandte Chemie- International Edition

IS - 3

ER -

Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

Abstract

UN SDGs

Keywords

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