Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

J.A. Parkinson; P. Muller; B. Shroder; N.A. Kratochwil; R.A. Coxall; A. Parkin; S. Parsons; P.J. Sadler

doi:10.1002/anie.200390110

Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

J.A. Parkinson, P. Muller, B. Shroder, N.A. Kratochwil, R.A. Coxall, A. Parkin, S. Parsons, P.J. Sadler

Pure And Applied Chemistry

Research output: Contribution to journal › Article

100 Citations (Scopus)

Abstract

Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.

Original language	English
Pages (from-to)	335-339
Number of pages	5
Journal	Angewandte Chemie
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/anie.200390110
Publication status	Published - 2003

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Keywords

photoreactions
novel platinum (IV) azide complexes
cancer cells
irradiation

Cite this

Parkinson, J. A., Muller, P., Shroder, B., Kratochwil, N. A., Coxall, R. A., Parkin, A., ... Sadler, P. J. (2003). Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes. Angewandte Chemie, 42(3), 335-339. https://doi.org/10.1002/anie.200390110

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Access to Document

10.1002/anie.200390110