Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

J.A. Parkinson; P. Muller; B. Shroder; N.A. Kratochwil; R.A. Coxall; A. Parkin; S. Parsons; P.J. Sadler

doi:10.1002/anie.200390110

Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

J.A. Parkinson, P. Muller, B. Shroder, N.A. Kratochwil, R.A. Coxall, A. Parkin, S. Parsons, P.J. Sadler

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

107 Citations (Scopus)

Abstract

Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.

Original language	English
Pages (from-to)	335-339
Number of pages	5
Journal	Angewandte Chemie
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/anie.200390110
Publication status	Published - 2003

Keywords

photoreactions
novel platinum (IV) azide complexes
cancer cells
irradiation

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title = "Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes",

abstract = "Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.",

keywords = "photoreactions , novel platinum (IV) azide complexes , cancer cells, irradiation",

author = "J.A. Parkinson and P. Muller and B. Shroder and N.A. Kratochwil and R.A. Coxall and A. Parkin and S. Parsons and P.J. Sadler",

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AU - Parkinson, J.A.

AU - Muller, P.

AU - Shroder, B.

AU - Kratochwil, N.A.

AU - Coxall, R.A.

AU - Parkin, A.

AU - Parsons, S.

AU - Sadler, P.J.

PY - 2003

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AB - Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.

KW - photoreactions

KW - novel platinum (IV) azide complexes

KW - cancer cells

KW - irradiation

U2 - 10.1002/anie.200390110

DO - 10.1002/anie.200390110

M3 - Article

VL - 42

SP - 335

EP - 339

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 3

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