Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

J.A. Parkinson, P. Muller, B. Shroder, N.A. Kratochwil, R.A. Coxall, A. Parkin, S. Parsons, P.J. Sadler

Research output: Contribution to journalArticle

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Abstract

Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.
LanguageEnglish
Pages335-339
Number of pages5
JournalAngewandte Chemie
Volume42
Issue number3
DOIs
Publication statusPublished - 2003

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Azides
Guanine
Platinum
Nucleotides
Ligands
Light
Neoplasms

Keywords

  • photoreactions
  • novel platinum (IV) azide complexes
  • cancer cells
  • irradiation

Cite this

Parkinson, J. A., Muller, P., Shroder, B., Kratochwil, N. A., Coxall, R. A., Parkin, A., ... Sadler, P. J. (2003). Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes. Angewandte Chemie, 42(3), 335-339. https://doi.org/10.1002/anie.200390110
Parkinson, J.A. ; Muller, P. ; Shroder, B. ; Kratochwil, N.A. ; Coxall, R.A. ; Parkin, A. ; Parsons, S. ; Sadler, P.J. / Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes. In: Angewandte Chemie. 2003 ; Vol. 42, No. 3. pp. 335-339.
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Parkinson, JA, Muller, P, Shroder, B, Kratochwil, NA, Coxall, RA, Parkin, A, Parsons, S & Sadler, PJ 2003, 'Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes' Angewandte Chemie, vol. 42, no. 3, pp. 335-339. https://doi.org/10.1002/anie.200390110

Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes. / Parkinson, J.A.; Muller, P.; Shroder, B.; Kratochwil, N.A.; Coxall, R.A.; Parkin, A.; Parsons, S.; Sadler, P.J.

In: Angewandte Chemie, Vol. 42, No. 3, 2003, p. 335-339.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

AU - Parkinson, J.A.

AU - Muller, P.

AU - Shroder, B.

AU - Kratochwil, N.A.

AU - Coxall, R.A.

AU - Parkin, A.

AU - Parsons, S.

AU - Sadler, P.J.

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KW - novel platinum (IV) azide complexes

KW - cancer cells

KW - irradiation

U2 - 10.1002/anie.200390110

DO - 10.1002/anie.200390110

M3 - Article

VL - 42

SP - 335

EP - 339

JO - Angewandte Chemie International Edition

T2 - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

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