Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes

J.A. Parkinson, P. Muller, B. Shroder, N.A. Kratochwil, R.A. Coxall, A. Parkin, S. Parsons, P.J. Sadler

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Abstract

Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells.
Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalAngewandte Chemie
Volume42
Issue number3
DOIs
Publication statusPublished - 2003

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Keywords

  • photoreactions
  • novel platinum (IV) azide complexes
  • cancer cells
  • irradiation

Cite this

Parkinson, J. A., Muller, P., Shroder, B., Kratochwil, N. A., Coxall, R. A., Parkin, A., ... Sadler, P. J. (2003). Nucleotide cross-linking induced by photoreactions of novel platinum (IV) azide complexes. Angewandte Chemie, 42(3), 335-339. https://doi.org/10.1002/anie.200390110